Elevated plasma C3 anaphylatoxin levels in rheumatoid arthritis patients.
Elevated plasma C3 anaphylatoxin levels in rheumatoid arthritis patients.
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类风湿性关节炎患者血浆 C3 过敏毒素水平升高。
DOI：
10.1002/art.1780301003
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发表时间：
1987
影响因子：
--
通讯作者：
Ruddy,S
中科院分区：
文献类型：
--
作者：
Moxley,G;Ruddy,S
由于类风湿性关节炎（RA）患者滑液中C3过敏毒素（C3 a和C3 a desArg）水平比退行性关节疾病或创伤性关节炎患者高7倍以上，我们对11例RA患者的C3和C5过敏毒素血浆水平进行了前瞻性研究。37例RA患者血浆中C_3含量为272.9 ± 106.1ng/ml，是9例正常人的2倍（P<0.05）。我们发现关节指数和疾病活动指数与血浆C3过敏毒素水平相关，相关值与血清C反应蛋白水平和魏氏红细胞沉降率相似。在关节指数和疾病活动指数与实验室检查结果、血浆C3 a水平、血清C反应蛋白水平和红细胞沉降率组合的相关性中，我们发现几乎任何一对实验室检查的相关性都比任何一项检查的相关性更强。
Because synovial fluid levels of the C3 anaphylatoxins, C3a and C3a desArg, are more than 7 times higher in patients with rheumatoid arthritis (RA) than in patients with degenerative joint disease or traumatic arthritis, we conducted a prospective study of plasma levels of C3 and C5 anaphylatoxins in 11 RA patients. The mean level of C3 anaphylatoxin in 37 RA plasma specimens was twice as high as that in samples obtained from 9 normal volunteers (272.9 ± 106.1 ng/ml versus 133.9 plusmn; 19.4 ng/ml) (P<0.05). We found that the joint index and the disease activity index were correlated with the plasma C3 anaphylatoxin level, and that the correlation values were similar to those for serum C‐reactive protein level and for the Westergren erythrocyte sedimentation rate. In correlations of the joint index and disease activity index with combinations of laboratory test results, the plasma C3a level, the serum C‐reactive protein level, and the erythrocyte sedimentation rate, we found that almost any pair of laboratory tests correlated more strongly than did any one test.