Skeletal response to alcohol
Skeletal response to alcohol
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DOI：
10.1097/00000374-200011000-00012
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发表时间：
2000-11-01
影响因子：
3.2
通讯作者：
Turner, RT
中科院分区：
文献类型：
--
作者：
Turner, RT
这篇综述简要评估了饮酒对骨骼和矿物质代谢的既定影响，并解决了需要进一步研究的争议领域。饮酒是骨质疏松症的一个危险因素，因为酗酒者经常出现骨量低、骨形成率降低和骨折发生率增加的情况。酒精还被证明可以减少健康人和动物的骨形成，并减少培养的成骨细胞的增殖。另一方面，在基于人群的研究中很难证明酒精引起的骨质流失和骨折率增加。事实上，大多数基于人群的研究表明，酒精和骨量之间存在正相关关系，并且骨折风险没有变化或降低。总体而言，证据普遍支持长期酗酒对男性骨骼产生有害影响，而轻度至中度饮酒则产生中性或总体有益的影响，尤其是对老年女性。后一种假定的有益效果可能是由于与绝经后骨质流失相关的骨重塑的年龄相关增加的减少。建议进行特定的研究领域来阐明饮酒对剂量和性别的影响，并确定细胞和分子的作用机制。这项拟议研究重点的目标是确定饮酒范围的风险程度，制定与维持骨骼健康相一致的饮酒指南，并制定适当的对策来预防或扭转酗酒对骨骼的有害影响。
This review briefly assesses the well-established effects of alcohol consumption on bone and mineral metabolism and addresses areas of controversy that need additional research. Alcohol consumption is a risk factor for osteoporosis based on the frequent finding of a low bone mass, decreased bone formation rate, and increased fracture incidence in alcoholics. Alcohol also has been shown to reduce bone formation in healthy humans and animals and to decrease proliferation of cultured osteoblastic cells. On the other hand, it has been difficult to demonstrate alcohol-induced bone loss and increased fracture rate in population-based studies. Indeed, most population-based studies have shown a positive association between alcohol and bone mass and no change or a decrease in fracture risk. Overall, the evidence generally supports a detrimental effect of chronic alcohol abuse on the skeleton of men and a neutral or generally beneficial effect of light to moderate alcohol consumption, especially in older women. This latter putative beneficial effect may be due to a reduction in the age-related increase in bone remodeling associated with postmenopausal bone loss. Specific areas of research are recommended to clarify the dose and sex effects of alcohol consumption and to determine cellular and molecular mechanisms of action. The goals of this proposed research emphasis are to determine the degree of risk for the range of alcohol consumption, to set guidelines of consumption compatible with maintaining bone health, and to develop appropriate countermeasures to prevent or reverse the detrimental skeletal effects of alcohol abuse.