Tuning in to the Voices: A Multisite fMRI Study of Auditory Hallucinations
Tuning in to the Voices: A Multisite fMRI Study of Auditory Hallucinations
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DOI：
10.1093/schbul/sbn140
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发表时间：
2009-01-01
影响因子：
6.6
通讯作者：
Mathalon, Daniel H.
中科院分区：
文献类型：
--
作者：
Ford, Judith M.;Roach, Brian J.;Mathalon, Daniel H.
简介：75%的精神分裂症患者会出现幻听或幻听。我们推测，精神分裂症患者的听觉皮层在经历幻觉时，会以处理外部声音（包括语音和非语音）为代价，对内部听觉通道进行音调性“调谐”。因此，我们预测有幻觉的患者对外部声刺激的听觉皮层激活比没有幻觉的患者要少。研究方法：在9个功能成像生物医学信息学研究网络（FBIRN）站点，收集了来自106名患者和111名健康对照受试者的全脑图像，同时受试者执行听觉目标检测任务。用FBIRN处理流处理数据。感兴趣区域分析从初级（BA41）和次级听觉皮层（BA42）、听觉联合皮层（BA22）和颞中回（BA21）提取激活值。根据前一周的症状评分，将患者分为幻觉者（n = 66）和非幻觉者（n = 40）。结果：幻觉者左侧初级听皮层（BA41）对探测音的激活低于非幻觉者。在右边没有看到这种效果。讨论内容：虽然“声音”是预期的感官体验，但似乎即使是初级听觉皮层也会“打开”和“调整”以处理外部声音为代价来处理内部声学信息。虽然这项研究的目的不是为了探索皮层对听觉资源的竞争，但我们能够利用这些数据并发现显著的影响，这可能是因为如此大的样本所提供的力量。
Introduction: Auditory hallucinations or voices are experienced by 75% of people diagnosed with schizophrenia. We presumed that auditory cortex of schizophrenia patients who experience hallucinations is tonically "tuned" to internal auditory channels, at the cost of processing external sounds, both speech and nonspeech. Accordingly, we predicted that patients who hallucinate would show less auditory cortical activation to external acoustic stimuli than patients who did not. Methods: At 9 Functional Imaging Biomedical Informatics Research Network (FBIRN) sites, whole-brain images from 106 patients and 111 healthy comparison subjects were collected while subjects performed an auditory target detection task. Data were processed with the FBIRN processing stream. A region of interest analysis extracted activation values from primary (BA41) and secondary auditory cortex (BA42), auditory association cortex (BA22), and middle temporal gyrus (BA21). Patients were sorted into hallucinators (n = 66) and nonhallucinators (n = 40) based on symptom ratings done during the previous week. Results: Hallucinators had less activation to probe tones in left primary auditory cortex (BA41) than nonhallucinators. This effect was not seen on the right. Discussion: Although "voices" are the anticipated sensory experience, it appears that even primary auditory cortex is "turned on" and "tuned in" to process internal acoustic information at the cost of processing external sounds. Although this study was not designed to probe cortical competition for auditory resources, we were able to take advantage of the data and find significant effects, perhaps because of the power afforded by such a large sample.