GAMMA-AMINOBUTYRIC ACID CONCENTRATION IN CEREBROSPINAL-FLUID IN SCHIZOPHRENIA
GAMMA-AMINOBUTYRIC ACID CONCENTRATION IN CEREBROSPINAL-FLUID IN SCHIZOPHRENIA
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DOI：
10.1111/j.1471-4159.1981.tb00579.x
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发表时间：
1981-01-01
影响因子：
4.7
通讯作者：
ROUX, JT
中科院分区：
文献类型：
--
作者：
MCCARTHY, BW;GOMES, UR;ROUX, JT
测定急性和精神分裂症患者脑脊液中GABA的浓度，测定有心理或人格障碍的患者脑脊液中GABA的浓度。慢性精神分裂症患者脑脊液中GABA的平均水平明显高于其他任何一组。没有发现其他统计学上的显著差异。统计分析显示，慢性精神分裂症患者脑脊液中GABA浓度升高不太可能是药物所致。这些结果被解释为慢性精神分裂症患者大脑中可能存在原发性或继发性gaba能过度活动的证据。
GABA concentration was determined in CSF of acute and schizophrenic patients, in persons with psychoorganic or personality disorders and in nonpsychiatric controls. The mean CSF GABA level in the chronic schizophrenic patients was significantly higher than in any of the other groups. No other statistically significant differences were found. Statistical analysis revealed that the elevated CSF GABA concentration in the chronic schizophrenic patients was unlikely to be caused by medication. These results are interpreted as evidence for possible primary or secondary GABAergic overactivity in the brain in chronic schizophrenia.