Motion sickness in the squirrel monkey.
Motion sickness in the squirrel monkey.
复制标题
松鼠猴晕动病。
DOI：
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发表时间：
1980
影响因子：
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通讯作者：
K. Brizzee
中科院分区：
文献类型：
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作者：
J. Ordy;K. Brizzee
由于松鼠猴与人类属于同一分类目，因此已被引入作为非人类灵长类动物模型，用于研究运动和太空病的易感性、预防、治疗和神经机制等方面。在这项关于敏感性的研究中，具体目的是检查垂直旋转和水平加速度组合、表型、性别、视觉线索、上午和下午测试以及重复测试暴露对呕吐反应的发生率、频率和潜伏期的影响。在 25 rpm 和 0.5 Hz 线性加速度下，呕吐发生率最高，为 89%，在 60 分钟内呕吐频率为 2.0 次，从测试开始起潜伏期为 19 分钟。在存在视觉提示的情况下，男性的易感性（由呕吐的发生率、频率和/或潜伏期定义）显着高于哥伦比亚表型，但在一天中的不同时段或两次连续的测试暴露中则不然。由于在引发运动刺激方面的催吐反应与人类非常相似，因此得出结论，松鼠猴是一种非常适合研究运动和太空病的灵长类动物模型。
Because it is of the same taxonomic order as man, the squirrel monkey has been introduced as a nonhuman primate model for the study of such aspects of motion and space sickness as susceptibility, prevention, treatment, and neural mechanisms. In this study on susceptibility, the specific aims were to examine the effects of combined vertical rotation and horizontal acceleration, phenotype, sex, visual cues, morning and afternoon testing, and repeated test exposures on incidence, frequency, and latency of emetic responses. The highest emetic incidence of 89%, with an emetic frequency of 2.0, during 60 min, and a latency of 19 min from onset of testing, occurred at 25 rpm and 0.5 Hz linear acceleration. Susceptibility--defined by incidence, frequency, and/or latency of emesis--was significantly higher in Bolivian than Colombian phenotypes, in the presence of visual cues, in males, but not at different periods of the day or with two successive test exposures. Since the emetic responses were quite similar to man in the eliciting motion stimuli, it was concluded that the squirrel monkey represents a very suitable primate model for studies of motion and space sickness.