Linking clinical variables to health-related quality of life in Parkinson's disease
Linking clinical variables to health-related quality of life in Parkinson's disease
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DOI：
10.1016/s1353-8020(01)00044-x
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发表时间：
2002-01-01
影响因子：
4.1
通讯作者：
Rodnitzky, RL
中科院分区：
文献类型：
--
作者：
Chrischilles, EA;Rubenstein, LM;Rodnitzky, RL
目的：确定帕金森病（PD）体征和症状与健康相关生活质量（HRQL）指标之间的时间点关系背景：PD评估中使用的临床指标传统上强调体征和症状。我们假设，这些措施将是密切相关的身体功能方面的HRQL，反映精神symptoms.Design/Methods：一个横断面研究的193神经科诊所PD患者采用自我管理的诊所和带回家的问卷调查和在人的临床检查和访谈。由PD体征和症状解释的差异对于身体功能是显著的，但对于所有其他HRQL维度仅是适度的。精神症状解释了更大比例的方差比身体症状的12个14 HRQL measurement.Conclusion：PD患者的幸福感，一般健康感知，健康满意度和整体HRQL的心理健康症状的强烈影响，更弱的身体症状的影响。PD患者的临床评估应包括心理健康和自我报告的HRQL评估。(C)2002爱思唯尔科技有限公司。保留所有权利。
Objective: Identify the point-in-time relationship between Parkinson's disease (PD) signs and symptoms and measures of health-related quality of life (HRQL).Background: Clinical measures used in PD assessments traditionally emphasize physical signs and symptoms. We hypothesized that these measures would be strongly associated with the physical function dimensions of HRQL that reflect mental symptoms.Design/methods: A cross-sectional study of 193 neurology clinic PD patients employed self-administered in-clinic and take-home questionnaires and in-person clinical examinations and interviews.Results: The variance explained by PD physical signs and symptoms was substantial for physical function, but only modest for all other HRQL dimensions. Mental symptoms explained a larger proportion of variance than physical symptoms for 12 of the 14 HRQL measures.Conclusion: PD patients' well-being, general health perceptions, health satisfaction and overall HRQL are strongly influenced by mental health symptoms and more weakly influenced by physical symptoms. Clinical evaluation of PD patients should include mental health and self-reported HRQL assessment. (C) 2002 Elsevier Science Ltd. All rights reserved.