Emerging therapeutic opportunities for skeletal restoration.
Emerging therapeutic opportunities for skeletal restoration.
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DOI：
10.1038/nrd3299
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发表时间：
2011-02
影响因子：
120.1
通讯作者：
Rosen, Clifford J.
中科院分区：
文献类型：
--
作者：
Kawai, Masanobu;Moedder, Ulrike I.;Khosla, Sundeep;Rosen, Clifford J.
骨质疏松症是一种以骨质疏松和骨折为特征的综合症，在男女中越来越普遍。这种疾病的既定疗法主要包括预防骨质流失的药物，如双膦酸盐和选择性雌激素受体调节剂。尽管这些药物在随机试验中已被证明可以减少骨折，但迫切需要能够进一步降低骨折风险而不会产生额外不良反应的治疗方法。甲状旁腺激素（teriparthritis）的引入，显着增加骨矿物质密度，虽然持续时间相对较短，提高了刺激骨形成的药物可能治愈骨质疏松症的期望。在概述了目前治疗骨质疏松症的方法后，本文综述了基于对骨骼生理学的最新见解的骨质疏松症的新兴治疗机会。这种新的策略不仅可以减少与年龄相关的骨丢失和相关的骨折风险，而且可以将骨矿物质密度恢复到健康水平。
Osteoporosis, a syndrome characterized by thin bones and fractures, has become more prevalent in both women and men. Established therapies for this disorder consist primarily of drugs that prevent bone loss, such as the bisphosphonates and selective estrogen receptor modulators. Although these drugs have been shown to reduce fractures in randomized trials, there is an urgent need for treatments that could lower fracture risk further without additional adverse effects. The introduction of parathyroid hormone (teriparatide), which significantly increases bone mineral density, albeit for a relatively short duration, raised expectations that drugs which stimulate bone formation might cure osteoporosis. After outlining current approaches to treating osteoporosis, this review focuses on emerging therapeutic opportunities for osteoporosis that are based on recent insights into skeletal physiology. Such novel strategies offer promise for not only reducing age-related bone loss and the associated risk of fractures, but restoring bone mineral density to healthy levels.
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