Dynamic signaling network for the specification of embryonic pancreas and liver progenitors.
Dynamic signaling network for the specification of embryonic pancreas and liver progenitors.
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DOI：
10.1126/science.1174497
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发表时间：
2009-06-26
期刊：
影响因子：
--
通讯作者：
Zaret KS
中科院分区：
文献类型：
--
作者：
Wandzioch E;Zaret KS
Studies of the formation of pancreas and liver progenitors have focused on individual inductive signals and cellular responses. Here we investigated how BMP, TGFβ, and FGF signaling pathways converge on the earliest genes that elicit pancreas and liver induction in mammalian embryos. The inductive network was found to be dynamic, changing within hours, and different signals functioned in parallel to induce different early genes. Two permutations of signals induced liver progenitor domains, revealing flexibility in cell programming. Also, the specification of pancreas and liver progenitors was restricted by the TGFβ pathway. These results findings may enhance progenitor cell specification from stem cells for biomedical purposes and explain incomplete programming in stem cell differentiation protocols.
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影响因子：
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作者：
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通讯作者：
Stainier, Didier Y. R.
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DOI：
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