Phosphorylation and progesterone receptor function.
Phosphorylation and progesterone receptor function.
复制标题
磷酸化和孕激素受体功能。
DOI：
10.1016/0960-0760(95)00098-k
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Poletti,A
中科院分区：
文献类型：
--
作者：
Weigel,NL;Bai,W;Zhang,Y;Beck,CA;Edwards,DP;Poletti,A
The progesterone receptor is a member of a superfamily of ligand activated transcription factors which includes the steroid receptors, thyroid hormone, retinoic acid and vitamin D receptors as well as a large number of proteins which are termed orphans because their ligands and/or their functions are unknown (Evans,1988; Wang et al, 1989). A variety of studies have shown that phosphorylation/dephosphorylation plays a major role in the regulation of the activity of numerous transcription factors. Phosphorylation can alter DNA binding, either by enhancing or inhibiting the activity, by changing DNA binding specificity or by altering interactions with other transcription factors (Englander et al, 1991; Prywes et al, 1988; Raychaudri et al, 1989; Boyle et al, 1991). In addition, phosphorylation is often important for transcriptional activation of the factors (Binetruy et al, 1991; Jackson et al, 1991). Moreover, transcription factors are frequently multiply phosphorylated and these phosphorylations may play different roles (Barber and Verma, 1987; Boyle et al, 1991). In some cases, both specific phosphorylations as well as specific dephosphorylations are required for full activity (Boyle et al, 1991).
