Tetrodotoxin inactivation of the gustatory cortex disrupts the effect of the N-methyl-d-aspartate antagonist ketamine on latent inhibition of conditioned taste aversion in rats
Tetrodotoxin inactivation of the gustatory cortex disrupts the effect of the N-methyl-d-aspartate antagonist ketamine on latent inhibition of conditioned taste aversion in rats
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DOI：
10.1016/s0304-3940(97)00897-5
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发表时间：
1998-01
影响因子：
2.5
通讯作者：
M. Gallo;E. Bielavská;Gabriel Roldán;J. Bureš
中科院分区：
文献类型：
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作者：
M. Gallo;E. Bielavská;Gabriel Roldán;J. Bureš
研究了非竞争性N-甲基-D-天冬氨酸（NMDA）受体拮抗剂氯胺酮对大鼠味觉厌恶学习潜伏抑制的影响。在三次预暴露于糖精钠（0.1%）后，全身注射氯胺酮（50 mg/kg）破坏了潜在的抑制作用。这种阻断不是由于氯胺酮的厌恶性质，因为三种糖精-氯胺酮配对不会产生糖精厌恶。此外，氯胺酮诱导的潜伏抑制阻断被河豚毒素注射（10 ng/μl）诱导的味觉皮层可逆失活破坏，每次预暴露后应用。一个特定的味觉皮层调解氯胺酮的影响进行了讨论。
The effect of the non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist ketamine on latent inhibition of taste aversion learning was studied in rats. Systemic injections of ketamine (50 mg/kg) applied after each of three preexposures to sodium saccharin (0.1%) disrupted the latent inhibition effect. The blockade was not due to aversive properties of ketamine, because three saccharin-ketamine pairings did not produce saccharin aversion. Moreover, the ketamine-induced blockade of latent inhibition was disrupted by tetrodotoxin injections (10 ng/μl)-induced reversible inactivation of gustatory cortex, applied after each preexposure. A specific gustatory cortex mediation of the ketamine effect is discussed.