Long Noncoding RNA Related to Cartilage Injury Promotes Chondrocyte Extracellular Matrix Degradation in Osteoarthritis
Long Noncoding RNA Related to Cartilage Injury Promotes Chondrocyte Extracellular Matrix Degradation in Osteoarthritis
复制标题
与软骨损伤相关的长非编码RNA促进骨关节炎中软骨细胞胞外基质降解
DOI：
10.1002/art.38309
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发表时间：
2014-04-01
影响因子：
13.3
通讯作者：
Ao, Yingfang
中科院分区：
文献类型：
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作者：
Liu, Qiang;Zhang, Xin;Ao, Yingfang
长非编码RNAs(Long Non Coding RNAs，LncRNAs)在多种生物过程中起着重要的调节作用，但对其在骨关节炎中的作用知之甚少。本研究的目的是检测lncRNA在关节软骨中的表达，并探讨软骨损伤相关的lncRNA(lncRNA-CIR)在骨性关节炎中的作用。
Long noncoding RNAs (lncRNAs) play crucial regulatory roles in diverse biologic processes, but knowledge of lncRNAs in osteoarthritis (OA) is limited. The aim of this study was to identify lncRNA expression in articular cartilage and to explore the function of cartilage injury–related lncRNAs (lncRNA‐CIR) in OA.