Monitoring regulatory T cells as a prognostic marker in lung transplantation.
Monitoring regulatory T cells as a prognostic marker in lung transplantation.
复制标题
监测调节性T细胞作为肺移植预后标记物。
DOI：
10.3389/fimmu.2023.1235889
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发表时间：
2023
影响因子：
7.3
通讯作者：
Krupnick, Alexander Sasha
中科院分区：
文献类型：
--
作者：
Khan, Mohammad Afzal;Lau, Christine L.;Krupnick, Alexander Sasha
关键词：
Lung transplantation is the major surgical procedure, which restores normal lung functioning and provides years of life for patients suffering from major lung diseases. Lung transplant recipients are at high risk of primary graft dysfunction, and chronic lung allograft dysfunction (CLAD) in the form of bronchiolitis obliterative syndrome (BOS). Regulatory T cell (Treg) suppresses effector cells and clinical studies have demonstrated that Treg levels are altered in transplanted lung during BOS progression as compared to normal lung. Here, we discuss levels of Tregs/FOXP3 gene expression as a crucial prognostic biomarker of lung functions during CLAD progression in clinical lung transplant recipients. The review will also discuss Treg mediated immune tolerance, tissue repair, and therapeutic strategies for achieving in-vivo Treg expansion, which will be a potential therapeutic option to reduce inflammation-mediated graft injuries, taper the toxic side effects of ongoing immunosuppressants, and improve lung transplant survival rates.
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影响因子：
7.3
作者：
Borges PA;Waclawiak I;Georgii JL;Fraga-Junior VDS;Barros JF;Lemos FS;Russo-Abrahão T;Saraiva EM;Takiya CM;Coutinho-Silva R;Penido C;Mermelstein C;Meyer-Fernandes JR;Canto FB;Neves JS;Melo PA;Canetti C;Benjamim CF
通讯作者：
Benjamim CF
影响因子：
5.6
作者：
Kazmi S;Khan MA;Shamma T;Altuhami A;Ahmed HA;Mohammed Assiri A;Broering DC
通讯作者：
Broering DC
DOI：
10.1111/ajt.14400
发表时间：
2018-01
期刊：
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
影响因子：
--
作者：
Badell IR;La Muraglia GM 2nd;Liu D;Wagener ME;Ding G;Ford ML
通讯作者：
Ford ML
影响因子：
4.9
作者：
Cutolo M;Soldano S;Gotelli E;Montagna P;Campitiello R;Paolino S;Pizzorni C;Sulli A;Smith V;Tardito S
通讯作者：
Tardito S
DOI：
10.1016/j.jid.2020.04.015
发表时间：
2020-12
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Shakya S;Mack JA;Alipour M;Maytin EV
通讯作者：
Maytin EV