Bioactive interpenetrating polymer networks for improving the electrode/neural-tissue interface
Bioactive interpenetrating polymer networks for improving the electrode/neural-tissue interface
复制标题
用于改善电极/神经组织界面的生物活性互穿聚合物网络
DOI：
10.1016/j.elecom.2017.04.015
复制
发表时间：
2017-06-01
影响因子：
5.4
通讯作者：
Wang, Liping
中科院分区：
文献类型：
--
作者：
Zhong, Cheng;Ke, Dingning;Wang, Liping
神经电极被认为是将电信号从生物信号转换为生物信号的桥梁，因此被用于各种实验和治疗目的。然而，仍然存在的一个重大挑战是实现在体内长期有效的电记录和刺激。在这里，我们报道了一种电化学共沉积的poly(3，4-ethylenedioxythiophene)/poly(styrenesulfonate)/nerve生长因子/地塞米松磷酸/聚乙烯醇/聚丙烯酸加合物互穿聚合物网络的研究，以改善电极/神经-组织界面。与对照电极相比，修饰后的电极在1 kHz时表现出明显更高的电容和更低的电化学阻抗(降低了约96%)。此外，在大鼠皮质植入6周后，对组织反应进行评估。与对照组相比，实验组电极/神经-组织界面的胶质纤维酸性蛋白的免疫染色强度明显降低，而神经元核的免疫染色强度明显增强。所有这些特性都是在体内慢性电生理应用中非常需要的。
The neural electrode is recognized as a bridge that transduces electrical signals from or into biosignals and is thus used for various experimental and therapeutic purposes. However, a major challenge that still remains is to achieve long-term effective electrical recording and stimulation in vivo. Here, we report an investigation of electrochemically co-deposited poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonate)/nerve growth factor/dexamethasone phosphate/poly(vinyl alcohol)/poly(acrylic add) interpenetrating polymer networks for improving the electrode/neural-tissue interface. After modification, the electrodes exhibit a substantially higher capacitance and lower electrochemical impedance (reduced by similar to 96%) at 1 kHz as compared to control electrodes. Furthermore, tissue response was evaluated after a 6-week implantation in the cortex of rats. Relative to the control group, the test group show significantly lower immunostaining intensity for glial fibrillary acidic protein and higher intensity for neuronal nuclei at the electrode/neural-tissue interface. All of these characteristics are greatly desired in chronic electrophysiological applications in vivo.