Palladium-catalyzed monoarylation of nitroalkanes
Palladium-catalyzed monoarylation of nitroalkanes
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DOI：
10.1021/jo010953v
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发表时间：
2002-01-11
影响因子：
3.6
通讯作者：
Buchwald, SL
中科院分区：
文献类型：
--
作者：
Vogl, EM;Buchwald, SL
描述了硝基烷烃的钯催化芳基化的通用方案。取代的芳基溴和芳基氯可以在温和条件下与多种硝基烷烃有效偶联，选择性地产生单芳基化产物。该方法可耐受多种官能团，包括酮、酯和烯烃。值得注意的是，与酮和酯芳基化相比，硝基烷烃的芳基化可以化学选择性地进行。
A general protocol for the Pd-catalyzed-arylation of nitroalkanes is described. Substituted aryl bromides as well as aryl chlorides can be coupled efficiently with a variety of nitroalkanes under mild conditions to selectively yield the monoarylated products. This method tolerates a number of functional groups including ketones, esters, and olefins. Notably, the arylation of nitroalkanes can be effected chemoselectively over ketone and ester arylation.