EFFECT OF LONG-TERM FISH OIL SUPPLEMENTATION ON VITAMIN-E STATUS AND LIPID-PEROXIDATION IN WOMEN
EFFECT OF LONG-TERM FISH OIL SUPPLEMENTATION ON VITAMIN-E STATUS AND LIPID-PEROXIDATION IN WOMEN
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DOI：
10.1093/jn/121.4.484
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发表时间：
1991-04-01
影响因子：
4.2
通讯作者：
GORBACH, SL
中科院分区：
文献类型：
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作者：
MEYDANI, M;NATIELLO, F;GORBACH, SL
15名年轻（22-35岁）和10名老年（51-71岁）女性每天接受6粒鱼油胶囊（Pro-Mega），提供总计1，680 mg二十碳五烯酸（EPA），720 mg二十二碳六烯酸（DHA），600 mg其他脂肪酸和6 IU维生素E。在补充之前和之后1、2和3个月收集血液。 所有女性的血浆EPA和DHA显著增加证实了依从性。 老年妇女的EPA和DHA的增加显著高于年轻妇女（EPA增加10倍，DHA增加2.5倍，而老年妇女和年轻妇女的EPA增加8倍，DHA增加2倍）。 花生四烯酸：EPA比率的下降在老年妇女中更为显著。 血浆总甘油三酯（TG）显著降低，多不饱和脂肪酸/饱和脂肪酸比值显著升高（P < 0.01）。 补充后血浆维生素E水平没有显著变化;然而，年轻女性补充3个月后，血浆维生素E显著低于1个月后。 维生素E：TG比值显著增加，维生素E：（EPA + DHA）显著降低。 所有妇女都显示出通过mo 2的补充，血浆过氧化脂质显着增加。 2个月后，老年妇女的脂质过氧化物水平显着高于年轻妇女。 过氧化脂质：TG比值随mo 3下降，但仍显著高于基线水平。 这些数据表明，虽然长期补充鱼油可能有利于降低血浆总TG，但血浆脂质对自由基攻击的敏感性增强。 此外，血浆维生素E：（EPA + DHA）的减少和血浆脂质过氧化物的增加，特别是在老年受试者中，表明鱼油胶囊的维生素E含量可能不足以提供足够的抗氧化保护。
Fifteen young (22-35 y) and 10 older (51-71 y) women received six capsules of fish oil (Pro-Mega)/d, providing a total of 1,680 mg eicosapentaenoic (EPA), 720 mg docosahexaenoic (DHA), 600 mg other fatty acids, and 6 IU vitamin E. Blood was collected before and after 1, 2 and 3 mo of supplementation. Compliance was confirmed by the significant increase in plasma EPA and DHA in all women. Older women had a significantly higher increase in EPA and DHA than did young women (10-fold increases in EPA and 2.5-fold increases in DHA vs. 8-fold in EPA and 2-fold in DHA for older and young women, respectively). The decrease in the arachidonic acid:EPA ratio was more dramatic in the older women. Plasma total triglycerides (TG) decreased significantly, and the ratio of polyunsaturated fatty acids to saturated fatty acids was significantly (P < 0.01) increased. Plasma vitamin E levels did not change significantly after supplementation; however, after 3 mo of supplementation by young women, plasma vitamin E was significantly lower than after 1 mo. The vitamin E:TG ratio was significantly increased and vitamin E:(EPA + DHA) significantly decreased. All women showed a significant increase in plasma lipid peroxide through mo 2 of supplementation. After 2 mo, older women had significantly higher lipid peroxide levels than young women. The lipid peroxide:TG ratio, which declined by mo 3, was still significantly higher than baseline. These data indicate that although long-term fish oil supplementation may be beneficial in reducing plasma total TG, susceptibility of plasma lipids to free radical attack is potentiated. Furthermore, the decrease in plasma vitamin E:(EPA + DHA) and increase in plasma lipid peroxide, particularly in the older subjects, indicates that vitamin E content of fish oil capsules may not be sufficient to provide adequate antioxidant protection.