Physical exercise induces FGF-2 and its mRNA in the hippocampus
Physical exercise induces FGF-2 and its mRNA in the hippocampus
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DOI：
10.1016/s0006-8993(97)00375-2
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发表时间：
1997-08-01
期刊：
影响因子：
2.9
通讯作者：
So, V
中科院分区：
文献类型：
--
作者：
GomezPinilla, F;Dao, L;So, V
临床和实验证据表明，身体活动对大脑功能有积极的影响;然而，运动如何影响大脑结构和功能的分子基础在很大程度上是未知的。我们研究了不同周期的自愿轮跑对碱性成纤维细胞生长因子及其mRNA在不同脑区表达的影响。核酸酶保护试验表明，海马是唯一的区域检查显示FGF-2 mRNA的变化，作为一个结果的运动。FGF-2 mRNA表达在跑轮后第4天达到高峰。FGF-2免疫反应，通常位于核周区的星形胶质细胞，运动后变得更强，并出现扩散到细胞质和星形胶质细胞的过程。定量的FGF-2-免疫反应性星形胶质细胞的密度增加之间的2和4个晚上运行在离散区域的海马。这些结果表明，运动调节FGF-2的表达，并表明生长因子可能是运动对大脑产生积极影响的介质。(C)1997年Elsevier Science B.V.
Clinical and experimental evidence indicate that physical activity has a positive impact on brain function; however, the molecular bases for how exercise affects the structure and function of the brain are largely unknown. We have investigated the influences of variable periods of voluntary wheel-running on the expression of basic fibroblast growth factor and its mRNA in various brain regions. Nuclease protection assays revealed that the hippocampus was the only region examined exhibiting changes in FGF-2 mRNA as a result of exercise. FGF-2 mRNA increased to reach a peak by the 4th night of wheel-running. FGF-2 immunoreactivity, normally located in the perinuclear area of astrocytes, following exercise became stronger and appeared to spread to the cytoplasm and processes of astrocytes. Quantification of the FGF-2-immunoreactive astrocytes showed an increase in density between 2 and 4 nights of running in discrete regions of the hippocampus. These results demonstrate that exercise regulates FGF-2 expression and suggest that growth factors are likely mediators of the positive effects of exercise on the brain. (C) 1997 Elsevier Science B.V.