THE EFFECT OF ETOMOXIR ON INSULIN SENSITIVITY IN TYPE-2 DIABETIC-PATIENTS
THE EFFECT OF ETOMOXIR ON INSULIN SENSITIVITY IN TYPE-2 DIABETIC-PATIENTS
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DOI：
10.1055/s-2007-1003271
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发表时间：
1992-03-01
影响因子：
2.2
通讯作者：
GRIES, FA
中科院分区：
文献类型：
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作者：
HUBINGER, A;WEIKERT, G;GRIES, FA
口服50 mg依托莫西酯引起胰岛素介导的葡萄糖摄取显著升高（33.1%）。在8例2型糖尿病患者中进行的安慰剂对照、双盲、随机研究中，采用正葡萄糖钳夹技术，葡萄糖代谢清除率（MCR）平均值从4.1 ± 0.9 mg/（kg.min）提高到5.4 ± 1.2 mg/（kg.min）（x ± SEM，P = 0.039）。血浆游离脂肪酸（FFA）水平，葡萄糖反调节激素，血脂和C-肽值在钳夹过程中没有不同后，verum和安慰剂。我们的结论是，依托莫西改善2型糖尿病患者的胰岛素敏感性。
Oral application of 50 mg Etomoxir caused a significant rise (33.1%) of insulin-mediated glucose uptake. This was shown in a placebo-controlled, double-blind randomized study in 8 type 2 diabetic patients by using the euglycemic clamp technique.The mean metabolic clearance rate of glucose (MCR) was raised from 4.1 +/- 0.9 mg/(kg.min) to 5.4 +/- 1.2 mg/(kg.min) (x +/- SEM, P = 0.039). Plasma levels of free fatty acids (FFA), glucose counterregulatory hormones, lipids and C-peptide values during the clamps were not different after verum and placebo. We conclude that Etomoxir improves insulin sensitivity in type 2 diabetic patients.