Naltrexone attenuates cue- but not drug-induced methamphetamine seeking: a possible mechanism for the dissociation of primary and secondary reward
Naltrexone attenuates cue- but not drug-induced methamphetamine seeking: a possible mechanism for the dissociation of primary and secondary reward
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DOI：
10.1016/j.brainres.2004.06.051
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发表时间：
2004-09-24
期刊：
影响因子：
2.9
通讯作者：
Yamamoto, T
中科院分区：
文献类型：
--
作者：
Anggadiredja, K;Sakimura, K;Yamamoto, T
本研究旨在阐明阿片系统在冰毒自我给药大鼠恢复冰毒寻找行为中的作用。在自我注射冰毒12天后，用生理盐水取代冰毒，导致杠杆按压反应(消退)逐渐减少。在消亡条件下，冰毒引发或再次暴露于以前与冰毒输注配对的线索显著增加了反应(恢复药物寻找)。在再次暴露于冰毒相关线索前30分钟给予纳曲酮可减弱寻求毒品行为的恢复。另一方面，给予该拮抗剂对冰毒诱发的恢复无影响。我们讨论了这些发现与初级和次级奖赏的分离之间的关系，认为阿片类药物机制导致了这种分离。此外，这些结果表明纳曲酮作为抗复发药物的可能性。(C)2004爱思唯尔B.V.保留所有权利。
The present study was aimed to clarify the role of the opioid system in the reinstatement of methamphetamine (METH)-seeking behavior in METH self-administering rats. Following 12 days of self-administration of METH, the replacement of METH with saline resulted in a gradual decrease in lever press responses (extinction). Under extinction conditions, METH-priming or re-exposure to cues previously paired with METH infusion markedly increased the responses (reinstatement of drug-seeking). Naltrexone administered 30 min before re-exposure to METH-associated cues attenuated reinstatement of drug-seeking behavior. On the other hand, administration of this antagonist had no effect on the reinstatement induced by METH-priming. We discussed these findings in relation with the dissociation of primary and secondary reward, suggesting that an opioid mechanism is responsible for this dissociation. Further, these results indicate the possibility of using naltrexone as an anti-relapse agent. (C) 2004 Elsevier B.V. All rights reserved.