Statistical genetic issues for genome-wide association studies.

Statistical genetic issues for genome-wide association studies.
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DOI:
10.1139/g10-062
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发表时间:
2010-11
期刊:
影响因子:
3.1
通讯作者:
Weir BS
Weir BS
中科院分区:
生物学3区
文献类型:
--
作者:
Weir BS

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基因分型技术现在允许快速和负担得起的人类百万SNP图谱的产生,导致相当大的活动关联映射。预计包括芸苔属在内的许多植物物种也具有类似的活性。这些植物群丛绘图活动需要与人类同样的质量控制和质量保证。随后的分析可能会借鉴这里用数量遗传学的语言描述的同一理论体系。
Genotyping technology now allows the rapid and affordable generation of million-SNP profiles for humans, leading to considerable activity in association mapping. Similar activity is anticipated for many plant species, including Brassica. These plant association mapping activities will require the same care in quality control and quality assurance as for humans. The subsequent analyses may draw upon the same body of theory that is described here in the language of quantitative genetics.