Adjuvant chemoradiation for gastric cancer: multicentric study of the Anatolian Society of Medical Oncology.
Adjuvant chemoradiation for gastric cancer: multicentric study of the Anatolian Society of Medical Oncology.
复制标题
DOI：
10.5754/hge11709
复制
发表时间：
2012-03
影响因子：
--
通讯作者：
M. Kucukoner;A. Işıkdoğan;E. Arpacı;M. Bilici;D. Uncu;B. Cetin;F. Dane;M. Inane;M. Kaplan;K. Çayır;T. Yetişyiğit;N. Ozdemir;A. Inal;S. Aksoy;N. Alkiş;S. B. Tekin;C. Eroglu;S. Turhal;M. Benekli;S. Buyukberber
中科院分区：
文献类型：
--
作者：
M. Kucukoner;A. Işıkdoğan;E. Arpacı;M. Bilici;D. Uncu;B. Cetin;F. Dane;M. Inane;M. Kaplan;K. Çayır;T. Yetişyiğit;N. Ozdemir;A. Inal;S. Aksoy;N. Alkiş;S. B. Tekin;C. Eroglu;S. Turhal;M. Benekli;S. Buyukberber
背景/目的本研究的目的是报告637例胃癌根治性切除术后辅助化放疗的临床结果。方法对2003-2010年间8个医学中心收治的637例IB-IV期(M0期)可切除胃癌患者的临床资料进行回顾性分析。患者接受5FU-亚叶酸钙治疗，放疗按INT-0116方案进行。结果637例患者的中位生存期(OS)为43.7个月，无复发生存期(RFS)为36.6个月。1、3、5年OS率分别为84%、45%、40%，RFS率分别为81%、45%、35%。血液毒性和胃肠道毒性(1-4级)发生率分别为35%和36.5%。单因素分析显示，肿瘤分级、T分期、N分期、手术方式(全胃切除或次全切除)、手术切缘(R0或R1)是影响RFS和OS的预后因素(p<；0.05)。多因素分析发现，T分期、N分期和手术切缘是影响OS的因素。T分期、N分期和Lauren分期是影响RFS的因素。结论在土耳其人群中，胃癌根治性切除后辅助化放疗是可行的，毒副反应可以接受。
BACKGROUND/AIMS The aims of this study were to report the clinical outcomes of adjuvant chemo-radiotherapy after curative resection in 637 patients with gastric cancer. METHODOLOGY The retrospective analysis included 637 patients with resectable gastric cancer and stage IB-IV (M0) from 8 medical centers between 2003 and 2010. The patients were treated with 5FU-leucovorin and radiotherapy according to Schema for INT-0116. RESULTS Of the 637 patients, the median of overall survival (OS) was 43.7 months and relapse free survival (RFS) was 36.6 months. OS rates were 84%, 45%, 40% while RFS rates were 81%, 45% and 35% at 1, 3 and 5-years, respectively. Hematological and gastrointestinal toxicities (grade 1-4) were observed in 35% and 36.5% of patients, respectively. In univariate analysis, according to the Lauren classification, tumor grade, T stage, N stage, type of operation (total gastrectomy or subtotal) and surgery resection margin (R0 or R1) were found as prognostic factors on RFS and OS (p<0.05). In multivariate analysis, T stage, N stage and surgical margins were found as effective factors on OS. T stage, N stage and Lauren classification were factors affecting RFS. CONCLUSIONS Adjuvant chemo-radiotherapy after curative resection of gastric cancer was feasible, with acceptable toxicities in the Turkish population.