No evidence for spontaneous cross‐frequency phase–phase coupling in the human hippocampus
No evidence for spontaneous cross‐frequency phase–phase coupling in the human hippocampus
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DOI：
10.1111/ejn.14608
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发表时间：
2019-11
影响因子：
3.4
通讯作者：
T. Rings;Roy Cox;T. Rüber;K. Lehnertz;J. Fell
中科院分区：
文献类型：
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作者：
T. Rings;Roy Cox;T. Rüber;K. Lehnertz;J. Fell
跨频相-相耦合(PPC)被认为在认知过程中发挥作用，特别是在睡眠期间的记忆巩固中。关于海马区是否存在自发的相-相耦合，已有有争议的结果报道。在这里，我们研究了在清醒状态和不同睡眠阶段从人的海马体获取的颅内脑电记录中的这一现象。我们估计了不同频段对之间相互作用的强度，并使用建立在不同无效假设的替代物评估了结果的统计学意义。只有在用不那么严格的替代物进行测试时，才能观察到自发相-相耦合的迹象。然而，当要求通过所有四个替代测试时，没有明显的相-相耦合迹象。总而言之，我们没有在人类海马体中检测到自发的跨频相-相耦合的证据。
Cross‐frequency phase–phase coupling (PPC) has been suggested to play a role in cognitive processing and, in particular, in memory consolidation during sleep. Controversial results have been reported regarding the existence of spontaneous phase–phase coupling in the hippocampus. Here, we investigated this phenomenon in intracranial EEG recordings from the human hippocampus acquired during waking state and different sleep stages. We estimated the strength of interactions between different pairs of frequency bands and evaluated the statistical significance of findings using surrogates that build on different null hypotheses. Indications for spontaneous phase–phase coupling were only observed when testing with less rigorous surrogates. When requiring that all four surrogate tests be passed, however, there were no significant indications for phase–phase coupling. In conclusion, we did not detect evidence for spontaneous cross‐frequency phase–phase coupling in the human hippocampus.