Cytokines, IBD, and colitis-associated cancer.
Cytokines, IBD, and colitis-associated cancer.
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细胞因子，IBD和结肠炎相关的癌症。
DOI：
10.1097/mib.0000000000000236
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发表时间：
2015-02
影响因子：
4.9
通讯作者：
Grivennikov SI
中科院分区：
文献类型：
--
作者：
Francescone R;Hou V;Grivennikov SI
炎症性肠病(IBD)是一种由于慢性炎症而导致肠道损伤的衰弱状况。此外，长期的炎症状态使人容易患结肠炎相关性癌症(CAC)。由于免疫细胞大量渗入结肠，免疫细胞产生的细胞因子在IBD和CAC的发生和发展中起主要作用。本文就多种关键细胞因子在IBD和CAC中的作用及其对免疫系统和基质细胞的影响作一综述。最后，我们将简要讨论目前针对细胞因子治疗IBD的治疗方法和临床试验。
Inflammatory bowel diseases (IBDs) are debilitating conditions that result in intestinal damage due to chronic inflammation. In addition, the perpetual state of inflammation predisposes individuals to the development of colitis associated cancer (CAC). Because of the immense immune cell infiltration into colon, cytokines produced by immune cells are major players in the initiation and progression of IBD and CAC. In this review, we will explore the functions of many key cytokines and their roles in IBD and CAC, as well as their influences on the immune system and stromal cells. Finally, we will briefly discuss current therapies and current clinical trials targeting cytokines in IBD.