SLOWING OF MORTALITY-RATES AT OLDER AGES IN LARGE MEDFLY COHORTS
SLOWING OF MORTALITY-RATES AT OLDER AGES IN LARGE MEDFLY COHORTS
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DOI：
10.1126/science.1411540
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发表时间：
1992-10-16
期刊：
影响因子：
56.9
通讯作者：
VAUPEL, JW
中科院分区：
文献类型：
--
作者：
CAREY, JR;LIEDO, P;VAUPEL, JW
一般认为，大多数物种的死亡率在老年时单调增加。研究发现，在被关在7 200个笼子里的120万只蝇群和被单独监禁的大约48 000只成年蝇群中，随着年龄的增长，死亡率趋于稳定并下降。因此，老年人的预期寿命随着年龄的增长而增加而不是减少。这些结果对老年学和衰老生物学中的几个核心概念提出了质疑：(1)衰老可以以年龄特异性死亡率的增加为特征；(2)几乎所有物种的基本死亡模式在老年时遵循相同的单一模式；(3)物种有绝对的寿命限制。
It is generally assumed for most species that mortality rates increase monotonically at advanced ages. Mortality rates were found to level off and decrease at older ages in a population of 1.2 million medflies maintained in cages of 7,200 and in a group of approximately 48,000 adults maintained in solitary confinement. Thus, life expectancy in older individuals increased rather than decreased with age. These results cast doubt on several central concepts in gerontology and the biology of aging: (i) that senescence can be characterized by an increase in age-specific mortality, (ii) that the basic pattern of mortality in nearly all species follows the same unitary pattern at older ages, and (iii) that species have absolute life-span limits.