A kinome of 2600 in the ciliate Paramecium tetraurelia
A kinome of 2600 in the ciliate Paramecium tetraurelia
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DOI：
10.1016/j.febslet.2009.10.029
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发表时间：
2009-11-19
期刊：
影响因子：
3.5
通讯作者：
Schultz, Joerg
中科院分区：
文献类型：
--
作者：
Bemm, Felix;Schwarz, Roland;Schultz, Joerg
蛋白激酶在细胞过程的调节中起着至关重要的作用。大多数真核生物保留大约 2.5% 的蛋白激酶基因。我们分析了单细胞纤毛虫草履虫的基因组，并鉴定了 2606 个激酶，约占其基因的 6.6%，代表了迄今为止最大的激酶组。与人类激酶相结合的基因树揭示了钙钙调蛋白调节亚家族的大规模扩展，强调了钙在 P. tetraurelia 生理学中的重要性。这些激酶仅嵌入 40 个结构域结构中，而人类中有 134 个结构域结构。这可能表明实现目标特异性的不同机制。 (C) 2009 年欧洲生化学会联合会。由 Elsevier B.V 出版。保留所有权利。
Protein kinases play a crucial role in the regulation of cellular processes. Most eukaryotes reserve about 2.5% of their genes for protein kinases. We analysed the genome of the single-celled ciliate Paramecium tetraurelia and identified 2606 kinases, about 6.6% of its genes, representing the largest kinome to date. A gene tree combined with human kinases revealed a massive expansion of the calcium calmodulin regulated subfamily, underlining the importance of calcium in the physiology of P. tetraurelia. The kinases are embedded in only 40 domain architectures, contrasting 134 in human. This might indicate different mechanisms to achieve target specificity. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.