Oestrogen regulates proliferation and differentiation of human islet‐derived precursor cells through oestrogen receptor alpha
Oestrogen regulates proliferation and differentiation of human islet‐derived precursor cells through oestrogen receptor alpha
复制标题
DOI：
10.1042/cbi20090390
复制
发表时间：
2010-05
影响因子：
3.9
通讯作者：
Zhenhua Ren;C. Zou;Huijun Ji;Y. A. Zhang
中科院分区：
文献类型：
--
作者：
Zhenhua Ren;C. Zou;Huijun Ji;Y. A. Zhang
E2（雌二醇-17 β）是一种重要的激素，调节各种细胞功能，包括胰岛素的产生。hIPC（人胰岛源性前体细胞）能够在体内和体外增殖和分化成响应于葡萄糖而分泌胰岛素的细胞。然而，E2对hIPC的影响目前尚不清楚。本研究发现，人IPCs表达ERα（oestrogen receptor alpha，雌激素受体α），而不表达ERβ，E2促进人IPCs的增殖，抑制其分化。虽然胎儿hIPC也表达ERα，但未观察到E2对胎儿hIPC的影响，表明E2在胰腺发育的不同阶段具有不同的作用。本研究提示E2可能通过ERα调节人胰岛素样前体细胞的增殖和分化，是控制成人胰腺β细胞更新的关键因素之一。
E2 (oestradiol‐17β) is an important hormone that regulates various cell functions including insulin production. hIPCs (human islet‐derived precursor cells) are capable of proliferating and differentiating into cells that secrete insulin in response to glucose in vivo and in vitro. However, the effect of E2 on hIPCs is currently unclear. In this study, we found that ERα (oestrogen receptor alpha), but not ERβ, was expressed on hIPCs, and E2 promoted the proliferation and inhibited the differentiation of adult hIPCs. Although fetal hIPCs also express ERα, no effect of E2 on the fetal hIPCs was observed, suggesting differing roles of E2 at different stages of pancreatic development. This study indicates that E2 may be one of the key factors that control the turnover of adult pancreatic β cells by regulating the proliferation and differentiation of adult hIPCs through ERα.