PD-1 Expression on Natural Killer Cells and CD8+ T Cells During Chronic HIV-1 Infection
PD-1 Expression on Natural Killer Cells and CD8+ T Cells During Chronic HIV-1 Infection
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DOI：
10.1089/vim.2011.0096
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发表时间：
2012-08-01
期刊：
影响因子：
2.2
通讯作者：
Goodier, Martin R.
中科院分区：
文献类型：
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作者：
Norris, Sonia;Coleman, Adam;Goodier, Martin R.
程序性死亡受体 1 (PD-1) 是 HIV-1 感染期间 T 细胞耗竭的重要标志。自然杀伤 (NK) 细胞在 HIV-1 感染期间失去其功能，而 PD-1 在其他慢性病毒和细菌感染期间在 NK 细胞上表达。在这里，与血清阴性对照相比，病毒血症和无病毒血症 HIV-1 血清阳性个体的 NK 细胞上 PD-1 表达增加。然而，PD-1 在一小部分 NK 细胞上表达，且表达频率低于在 CD8(+) T 细胞中观察到的表达频率。用 IL-15 长期培养后，一小部分 NK 细胞和 CD8(+) T 细胞也能诱导 PD-1。 PD-1 水平升高与 NK 细胞增殖有限有关，这可能会对慢性 HIV-1 感染期间 NK 细胞的维持产生影响。
Programmed death receptor 1 (PD-1) is an important marker of T-cell exhaustion during HIV-1 infection. Natural killer (NK) cells lose their functional capacity during HIV-1 infection, and PD-1 is expressed on NK cells during other chronic viral and bacterial infections. Here, PD-1 expression was increased on NK cells from both viremic and aviremic HIV-1-seropositive individuals, compared to seronegative controls. However, PD-1 was expressed on a small subset of NK cells and at lower frequency than that observed for CD8(+) T cells. PD-1 was also induced on a minor fraction of NK cells and CD8(+) T cells after long-term culture with IL-15. Raised levels of PD-1 were associated with limited NK cell proliferation, which may have consequences for their maintenance during chronic HIV-1 infection.