Biodistribution of a novel antiestrogen (Analog II) in the mouse and rat.
Biodistribution of a novel antiestrogen (Analog II) in the mouse and rat.
复制标题
新型抗雌激素（类似物 II）在小鼠和大鼠体内的生物分布。
DOI：
10.1080/07435809009033005
复制
发表时间：
1990
影响因子：
2.1
通讯作者：
Basmadjian,GP
中科院分区：
文献类型：
--
作者：
Griffin,MT;Pento,JT;Magarian,RA;Mousissian,GK;Basmadjian,GP
在小鼠和大鼠中测定了新的抗雌激素类似物II的生物抑制作用。氚化产物[3 H]-类似物II由新英格兰核制备，并通过制备色谱法使用硅胶和石油醚/二氯甲烷（80：20）纯化。由于类似物II的疏水性质，脂肪组织具有最高的摄取。小鼠子宫组织中的摄取量第二高，高于大鼠中的摄取量。小鼠和大鼠之间生物分布的差异可以部分解释先前在这两种动物物种中观察到的类似物II生物活性的差异。
The biostribution of a novel antiestrogen Analog II was determined in the mouse and rat. The tritiated product, [3H]-Analog II was prepared by New England Nuclear and was purified by preparative chromatography using silica gel and petroleum ether/methylene chloride (80:20). The fat tissue had the highest uptake due to the hydrophobic nature of Analog II. The second highest uptake was in the mouse uterine tissue which was greater than that observed in the rat. The differences in biodistribution between the mouse and rat may partially explain the differences in biological activity of Analog II previously observed in these two animal species.