Absence of correlation between IL-28B gene polymorphisms and the clinical presentation of chronic hepatitis B in an Amazon Brazilian population.
Absence of correlation between IL-28B gene polymorphisms and the clinical presentation of chronic hepatitis B in an Amazon Brazilian population.
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DOI：
10.1155/2014/534534
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Vallinoto AC
中科院分区：
文献类型：
--
作者：
Conde SR;Rocha LL;Ferreira VM;Monteiro JC;Filgueiras NK;Lins PA;dos Santos BT;Freitas FB;Graça Eda S;Demachki S;de Araújo MT;Ishak R;Vallinoto AC
目标。本研究从亚马逊东部地区的一个病例研究中调查了IL-28B基因rs12979860和rs8099917在慢性乙型肝炎患者中的流行情况。方法：研究方法。在2011年5月至2012年12月期间，共评估了65名慢性感染的乙肝患者和97名抗-HBc和抗-HBs阳性的健康受试者(对照组)。根据临床、病理、生化、血液学和病毒学变量，患者组被指定为非活动携带者、慢性肝炎无肝硬化组和慢性肝炎肝硬化组。用实时定量聚合酶链式反应对患者进行基因分型。结果。感染组rs12979860多态频率(32.3%CC、41.5%CT和26.2%TT)与对照组(35%CC、47.4%CT和17.6%TT)相似，rs8099917多态频率(7.7%GG、35.4%GT和56.9%TT与7.2%GG、35.1%GT和57.7%TT)也相似。Rs12979860和rs8099917基因多态性与临床表现的相关性无统计学意义。结论。总之，这些多态在感染组和对照组中的分布相似，表明它们与受检人群中乙肝的易感性和临床演变无关。
Objective. The present study investigated the prevalence of the IL-28B polymorphisms rs12979860 and rs8099917 in chronic hepatitis B patients from a case study in Eastern Amazonia. Methods. In total, 65 chronically infected HBV patients and 97 healthy subjects who were anti-HBc and anti-HBs positive (control group) were evaluated between May 2011 and December 2012. The groups of patients were designated as inactive carriers, chronic hepatitis without cirrhosis, and chronic hepatitis with cirrhosis based on clinical, pathological, biochemical, hematological, and virological variables. The patients were genotyped using quantitative real-time PCR. Results. The frequencies of the rs12979860 polymorphism were similar between the infected group (32.3% CC, 41.5% CT, and 26.2 TT) and the control population (35% CC, 47.4% CT, and 17.6% TT), and the frequencies of the rs8099917 polymorphism (7.7% GG, 35.4% GT, and 56.9% TT versus 7.2% GG, 35.1% GT, and 57.7% TT) were also similar in both groups. The associations between the rs12979860 and rs8099917 polymorphisms and the clinical manifestations were not statistically significant. Conclusion. In conclusion, these polymorphisms had a similar distribution between infected and control groups, indicating that they were not associated with susceptibility and the clinical evolution of hepatitis B in the examined population.
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影响因子：
4.3
作者：
Lv, Guo-Cai;Ma, Wen-Jiang;Yang, Yi-Da
通讯作者：
Yang, Yi-Da
影响因子：
13.5
作者：
Bedossa, P;Poynard, T
通讯作者：
Poynard, T
中国汉族人群白细胞介素28B与乙型肝炎病毒感染的表达及基因多态性
影响因子：
6.7
作者：
Li, Wanyu;Jiang, Yanfang;Niu, Junqi
通讯作者：
Niu, Junqi
DOI：
10.1086/657146
发表时间：
2010-12-01
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Martin MP;Qi Y;Goedert JJ;Hussain SK;Kirk GD;Hoots WK;Buchbinder S;Carrington M;Thio CL
通讯作者：
Thio CL
影响因子：
8.2
作者：
Li, MC;Wang, HY;He, SH
通讯作者：
He, SH