Response properties of single auditory nerve fibers in the mouse
Response properties of single auditory nerve fibers in the mouse
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DOI：
10.1152/jn.00574.2004
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发表时间：
2005-01-01
影响因子：
2.5
通讯作者：
Liberman, MC
中科院分区：
文献类型：
--
作者：
Taberner, AM;Liberman, MC
转基因和突变系的出现使小鼠成为研究内耳的有价值的模型，并且通过单听神经（AN）纤维的记录可以获得了解耳蜗功能的强大窗口。这项研究首次系统地描述了小鼠 AN 纤维的自发和声诱发放电特性，特别是 CBA/CaJ 和 C57BL/6 品系，这两种品系均常用于听觉研究。分析了来自 CBA/CaJ 的 196 根 AN 纤维和来自 C57BL/6 的 58 根 AN 纤维的响应特性，包括自发率 (SR)、调谐曲线、速率与水平函数、动态范围、响应适应、锁相以及 SR 和这些响应特性之间的关系。唯一显着的品系间差异是 C57BL/6 中高频阈值的升高。一般来说，小鼠 AN 纤维表现出与其他哺乳动物相似的反应：调谐的清晰度随着特征频率的增加而增加，特征频率的范围为 2.5 至 70 kHz； SR 范围为 0 至 120 sp/s，SR 较低的光纤（
The availability of transgenic and mutant lines makes the mouse a valuable model for study of the inner ear, and a powerful window into cochlear function can be obtained by recordings from single auditory nerve ( AN) fibers. This study provides the first systematic description of spontaneous and sound-evoked discharge properties of AN fibers in mouse, specifically in CBA/CaJ and C57BL/6 strains, both commonly used in auditory research. Response properties of 196 AN fibers from CBA/CaJ and 58 from C57BL/6 were analyzed, including spontaneous rates (SR), tuning curves, rate versus level functions, dynamic range, response adaptation, phase-locking, and the relation between SR and these response properties. The only significant interstrain difference was the elevation of high-frequency thresholds in C57BL/6. In general, mouse AN fibers showed similar responses to other mammals: sharpness of tuning increased with characteristic frequency, which ranged from 2.5 to 70 kHz; SRs ranged from 0 to 120 sp/s, and fibers with low SR (