Prodromal symptoms before onset of manic-depressive disorder suggested by first hospital admission histories
Prodromal symptoms before onset of manic-depressive disorder suggested by first hospital admission histories
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DOI：
10.1097/00004583-200010000-00011
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发表时间：
2000-10-01
影响因子：
13.3
通讯作者：
Sussex, JN
中科院分区：
文献类型：
--
作者：
Egeland, JA;Hostetter, AM;Sussex, JN
目的：儿童和青少年躁狂抑郁症或 I 型双相情感障碍 (BPI) 研究的首要任务是寻找该疾病的早期预测因素。方法：对 58 名确诊为 BPI 的成年患者（32 名男性/26 名女性）样本的医疗记录数据进行审查和系统编码，以确定本次阿米什研究的前驱特征和可能的症状模式。结果：最常报告的症状包括情绪的阵发性变化（抑郁和易怒）和精力以及愤怒失控，没有显着的性别差异。 16 岁之前最常报告的症状随年龄增长而变化。首次症状出现与记录的 BPI 综合征发作之间的时间间隔为 9 至 12 年。结论：数据提出了关于特定症状和行为的可检验假设，这些假设可能有助于早期发现罹患躁狂抑郁症的最高风险儿童。
Objective: A priority for research on manic-depressive or bipolar I disorder (BPI) for children and adolescents has been to search for early predictors of the illness. Method: Medical record data were reviewed and systematically coded for a sample of 58 adult patients (32 males/26 females) with confirmed diagnoses of BPI to identify prodromal features and possible patterns of symptoms from this Amish Study. Results: The most frequently reported symptoms included episodic changes in mood (depressed and irritable) and energy plus anger dyscontrol, with no significant gender differences. A progression of ages is seen for the most commonly reported symptoms prior to age 16. The time interval was 9 to 12 years between appearance of the first symptoms and onset of a documented BPI syndrome. Conclusions: The data suggest testable hypotheses about specific symptoms and behaviors that may be useful for the early detection of children at highest risk for developing manic-depressive disorder.