Nuclear Pore Complex: From Structural View to Chemical Tools.
Nuclear Pore Complex: From Structural View to Chemical Tools.
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DOI：
10.1016/j.chembiol.2015.10.001
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发表时间：
2015-10
影响因子：
--
通讯作者：
R. Wong
中科院分区：
文献类型：
--
作者：
R. Wong
核孔复合体是细胞质和细胞核之间的大分子转门，控制蛋白质、RNA和病毒的运输。巨大的NPC结构极其复杂。在这里，我重点介绍几个关于NPC结构的最新发现，并简要讨论化学生物学家如何利用这些信息来设计合成设备和改进核药物输送策略。
Nuclear pore complexes (NPCs) are the macromolecular turnstiles between the cytoplasm and the nucleus that control the trafficking of proteins, RNAs and viruses. The giant NPC structures are extremely complex. Here, I highlight several recent findings on NPC architectures, and briefly discuss how chemical biologists might use this information to design synthetic devices and improve strategies for nuclear drug delivery.