Modulation of cognition-specific cortical activity by gonadal steroids: A positron-emission tomography study in women
Modulation of cognition-specific cortical activity by gonadal steroids: A positron-emission tomography study in women
复制标题
DOI：
10.1073/pnas.94.16.8836
复制
发表时间：
1997-08-05
影响因子：
11.1
通讯作者：
Weinberger, DR
中科院分区：
文献类型：
--
作者：
Berman, KF;Schmidt, PJ;Weinberger, DR
从动物研究中有大量证据表明性腺类固醇激素调节神经元活动并影响行为，为了直接在人类中研究这一点，我们使用(H2O)-O-15正电子发射断层扫描测量了年轻女性在4-5个月的三种药物控制激素条件下的区域脑血流量（rCBF）：促性腺激素释放激素激动剂醋酸丙烯醚（Lupron）、Lupron联合雌二醇替代、Lupron联合黄体酮替代诱导的卵巢抑制。雌二醇和黄体酮在双盲交叉设计中使用，每次在(i)威斯康星卡片分类测试期间进行正电子发射断层扫描，这是一种神经心理学测试，从生理上激活前额叶皮层（PFC）和相关的皮层网络，包括下顶叶和后外侧颞回，以及（ii）无延迟匹配样本的感觉运动控制任务。最引人注目的是，PFC的rCBF没有增加。当在Lupron方案中加入黄体酮或雌激素时，rCBF的激活模式随着顶叶和颞叶灶的增强和背外侧PFC激活的恢复而正常化。这些数据直接证明了激素环境调节人类认知相关的神经活动。
There is considerable evidence from animal studies that gonadal steroid hormones modulate neuronal activity and affect behavior, To study this in humans directly, we used (H2O)-O-15 positron-emission tomography to measure regional cerebral blood flow (rCBF) in young women during three pharmacologically controlled hormonal conditions spanning 4-5 months: ovarian suppression induced by the gonadotropin-releasing hormone agonist leuprolide acetate (Lupron), Lupron plus estradiol replacement, and Lupron plus progesterone: replacement. Estradiol and progesterone were administered in a double-blind cross-over design, On each occasion positron-emission tomography scans were performed during (i) the Wisconsin Card Sorting Test, a neuropsychological test that physiologically activates prefrontal cortex (PFC) and an associated cortical network including inferior parietal lobule and posterior inferolateral temporal gyrus, and (ii) a no-delay matching-to-sample sensorimotor control task, During treatment with Lupron alone (i.e., with virtual absence of gonadal steroid hormones), there was marked attenuation of the typical Wisconsin Card Sorting Test activation pattern even tough task performance did not change, Most strikingly, there was no rCBF increase in PFC. When either progesterone or estrogen nas added to the Lupron regimen, there was normalization of the rCBF activation pattern with augmentation of the parietal and temporal foci and return of the dorsolateral PFC activation, These data directly demonstrate that the hormonal milieu modulates cognition-related neural activity in humans.