Bioinformatics analysis of the prognostic value of Tripartite Motif 28 in breast cancer.
Bioinformatics analysis of the prognostic value of Tripartite Motif 28 in breast cancer.
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Tripartite Motif 28对乳腺癌预后价值的生物信息学分析
DOI：
10.3892/ol.2017.5764
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发表时间：
2017-04
期刊：
影响因子：
2.9
通讯作者：
Zhang Q
中科院分区：
文献类型：
--
作者：
Hao L;Leng J;Xiao R;Kingsley T;Li X;Tu Z;Yang X;Deng X;Xiong M;Xiong J;Zhang Q
Tripartite motif containing 28 （TRIM28）是一种转录调节因子，在多种组织和细胞类型中作为kr<s:1> ppel相关盒状锌指结构域蛋白的重要辅助抑制因子。越来越多的研究对TRIM28的功能进行了研究；然而，其在乳腺癌（BC）中的预后价值尚不清楚。在本研究中，TRIM28在癌组织样本中的表达明显高于健康组织样本。此外，TRIM28的表达与BC患者的几个临床病理特征，如p53突变、肿瘤复发和肿瘤的Elston分级显著相关。此外，我们还建立了一个蛋白质-蛋白质相互作用网络来说明TRIM28与其他蛋白质的相互作用。使用Kaplan-Meier Plotter数据库研究TRIM28在BC患者中的预后价值，结果显示TRIM28的高表达是BC患者预后不良的预测因子。总之，本研究的结果表明，TRIM28为BC患者提供了生存优势，除了是治疗BC的治疗靶点外，它还是一种新的预后生物标志物。
Tripartite motif containing 28 (TRIM28) is a transcriptional regulator acting as an essential corepressor for Krüppel-associated box zinc finger domain-containing proteins in multiple tissue and cell types. An increasing number of studies have investigated the function of TRIM28; however, its prognostic value in breast cancer (BC) remains unclear. In the present study, the expression of TRIM28 was identified to be significantly higher in cancerous compared with healthy tissue samples. Furthermore, it was demonstrated that TRIM28 expression was significantly correlated with several clinicopathological characteristics of patients with BC, such as p53 mutation, tumor recurrence and Elston grade of the tumor. In addition, a protein-protein interaction network was created to illustrate the interactions of TRIM28 with other proteins. The prognostic value of TRIM28 in patients with BC was investigated using the Kaplan-Meier Plotter database, which revealed that high expression of TRIM28 is a predictor of poor prognosis in patients with BC. In conclusion, the results of the present study indicate that TRIM28 provides a survival advantage to patients with BC and is a novel prognostic biomarker, in addition to being a therapeutic target for the treatment of BC.