Dual-mode ultrasound transducer for image-guided interstitial thermal therapy
Dual-mode ultrasound transducer for image-guided interstitial thermal therapy
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DOI：
10.1016/j.ultrasmedbio.2007.09.011
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发表时间：
2008-04-01
影响因子：
2.9
通讯作者：
Cathignol, Dominique
中科院分区：
文献类型：
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作者：
Bouchoux, Guillaume;Lafon, Cyril;Cathignol, Dominique
深部肿瘤可以通过微创间质超声热疗法进行治疗。一个发射高强度声波的微型换能器与目标区域接触，以诱导局部热坏死。为了使该技术有效，必须实现探头的精确定位和治疗监测。压电复合材料技术用于获得高质量的成像和有效的治疗与同一换能器。原型的设计和建造是兼容的，P内镜方法治疗胆管中的胆管癌。换能器的尺寸为2.5 x 7.5 mm（2），圆柱形聚焦在10 mm处，中心频率为11 MHz。换能器效率测得为71%，和脉冲响应对应的轴向分辨率为0.2毫米。在体外试验中进行的猪肝样品中，病变高达10毫米的深度诱导。通过机械旋转换能器获得B型图像。以三种方式监测治疗：（i）经典M模式图像，（ii）加热过程中超声线局部变形的图像和（iii）治疗前后辐射力在组织中诱导的位移比较。压电复合材料的成功应用为组织间超声热疗开辟了新的前景。
Deep-seated tumors can be treated by minimally invasive interstitial ultrasound thermal therapy. A miniature transducer emitting high-intensity acoustic waves is placed in contact with the targeted area to induce local thermal necrosis. Accurate positioning of the probe and treatment monitoring must be achieved for the technique to be effective. A piezocomposite technology was used for obtaining both high-quality imaging and effective treatment with the same transducer. Prototypes were designed and built to be compatible with an,P endoscopic approach for treating cholangiocarcinomas in the biliary ducts. The transducer had dimensions of 2.5 x 7.5 mm(2), it was cylindrically focused at 10 mm and it was operated at a center frequency of 11 MHz. Transducer efficiency was measured at 71%, and the impulse response corresponded to an axial resolution of 0.2 mm. In-vitro tests were conducted on samples of pig liver in which lesions up to 10 mm in depth were induced. B-mode images were obtained by mechanically rotating the transducer. Treatments were monitored in three ways: (i) classical M-mode images, (ii) images of local deformation of ultrasound lines during heating and (iii) comparison of the displacements induced in the tissue by radiation force, before and after treatments. The successful use of piezocomposite materials to manufacture dual-mode transducers opens new perspectives for interstitial ultrasound thermal therapy.