DISSOCIATION OF HUMAN MID-DORSOLATERAL FROM POSTERIOR DORSOLATERAL FRONTAL-CORTEX IN MEMORY PROCESSING
DISSOCIATION OF HUMAN MID-DORSOLATERAL FROM POSTERIOR DORSOLATERAL FRONTAL-CORTEX IN MEMORY PROCESSING
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DOI：
10.1073/pnas.90.3.873
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发表时间：
1993-02-01
影响因子：
11.1
通讯作者：
MEYER, E
中科院分区：
文献类型：
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作者：
PETRIDES, M;ALIVISATOS, B;MEYER, E
对非人类灵长类动物的研究已经证明，由细胞结构区46和9组成的中背外侧额叶皮层在非空间自我有序工作记忆任务的表现中起着关键作用，而紧邻的后背外侧额叶皮层（区8）对视觉条件联想任务的学习和表现至关重要。本研究使用正电子发射断层扫描和磁共振成像来证明，在人脑中，侧额叶皮层的这两个功能不同的细分存在。这些发现提供了直接的证据，证明就像在猴子的大脑中一样，人类的侧额叶皮层在功能上是异质的，在这两个物种中，相似的解剖区域构成了相似功能的基础。
Work with non-human primates had previously demonstrated that the mid-dorsolateral frontal cortex, which comprises cytoarchitectonic areas 46 and 9, plays a critical role in the performance of nonspatial self-ordered working memory tasks, whereas the immediately adjacent posterior dorsolateral frontal cortex (area 8) is critical for the learning and performance of visual conditional associative tasks. The present study used positron emission tomography with magnetic resonance imaging to demonstrate the existence, within the human brain, of these two functionally distinct subdivisions of the lateral frontal cortex. These findings provide direct evidence that, just as in the monkey brain, the human lateral frontal cortex is functionally heterogeneous and that comparable anatomical areas underlie similar functions in the two species.