Endoplasmic reticulum stress-related inflammation and cardiovascular diseases.
Endoplasmic reticulum stress-related inflammation and cardiovascular diseases.
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DOI：
10.4061/2011/259462
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发表时间：
2011
影响因子：
2
通讯作者：
Oike Y
中科院分区：
文献类型：
--
作者：
Gotoh T;Endo M;Oike Y
内质网（ER）是蛋白质合成和成熟的场所，这些蛋白质被设计用于分泌或定位在细胞膜上。来自细胞内外的各种类型的压力干扰ER功能，从而导致未折叠或错误折叠的蛋白质在ER中积累。为了改善和维持ER对抗这种应激的功能，ER应激反应途径被激活。然而，当压力延长或严重时，细胞凋亡途径被激活以去除受损细胞。最近报道，ER应激途径也参与炎症反应，由此炎症诱导ER应激，并且ER应激诱导炎症反应。因此，ER应激反应途径以各种方式参与各种疾病，包括心血管疾病如动脉粥样硬化和缺血性疾病。ER应激通路可能是治疗这些疾病的新靶点。
The endoplasmic reticulum (ER) is the site of synthesis and maturation of proteins designed for secretion or for localization on the cell membrane. Various types of stress from both inside and outside cells disturb ER function, thus causing unfolded or misfolded proteins to accumulate in the ER. To improve and maintain the ER functions against such stresses, the ER stress response pathway is activated. However, when the stress is prolonged or severe, apoptosis pathways are activated to remove damaged cells. It was recently reported that the ER stress pathway is also involved in the inflammatory response, whereby inflammation induces ER stress, and ER stress induces an inflammatory response. Therefore, the ER stress response pathway is involved in various diseases, including cardiovascular diseases such as atherosclerosis and ischemic diseases, in various ways. The ER stress pathway may represent a novel target for the treatment of these diseases.