FUNCTIONAL REGIONS OF THE ENVELOPE GLYCOPROTEIN OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1
FUNCTIONAL REGIONS OF THE ENVELOPE GLYCOPROTEIN OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1
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DOI：
10.1126/science.3629244
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发表时间：
1987-09-11
期刊：
影响因子：
56.9
通讯作者：
SODROSKI, J
中科院分区：
文献类型：
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作者：
KOWALSKI, M;POTZ, J;SODROSKI, J
人类免疫缺陷病毒 1 型 (HIV-1) 的包膜在病毒进入宿主细胞的过程中以及病毒对携带 CD4 分子的淋巴细胞的细胞病变中起着核心作用。影响包膜糖蛋白在 CD4+ 细胞中形成合胞体的能力的突变可分为五组：减少包膜蛋白与 CD4 分子结合的突变、阻止结合后融合反应的突变、破坏包膜糖蛋白在膜中锚定的突变、影响包膜糖蛋白两个亚基结合的突变，以及影响包膜糖蛋白与 CD4 分子结合的突变。 那些影响包膜前体蛋白翻译后蛋白水解加工的因素。这些发现提供了 HIV 包膜糖蛋白的功能模型。
The envelope of the human immunodeficiency virus type 1 (HIV-1) plays a central role in the process of virus entry into the host cell and in the cytopathicity of the virus for lymphocytes bearing the CD4 molecule. Mutations that affect the ability of the envelope glycoprotein to form syncytia in CD4+ cells can be divided into five groups: those that decrease the binding of the envelope protein to the CD4 molecule, those that prevent a post-binding fusion reaction, those that disrupt the anchorage of the envelope glycoprotein in the membrane, those that affect the association of the two subunits of the envelope glycoprotein, and those that affect post-translational proteolytic processing of the envelope precursor protein. These findings provide a functional model of the HIV envelope glycoprotein.