ACUTE EFFECT OF AN ANTIHYPERTENSIVE DRUG, LABETALOL, ON UTEROPLACENTAL BLOOD-FLOW
ACUTE EFFECT OF AN ANTIHYPERTENSIVE DRUG, LABETALOL, ON UTEROPLACENTAL BLOOD-FLOW
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DOI：
10.1111/j.1471-0528.1982.tb04719.x
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发表时间：
1982-01-01
期刊：
影响因子：
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通讯作者：
SARBY, B
中科院分区：
文献类型：
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作者：
LUNNELL, NO;NYLUND, L;SARBY, B
在8名先兆子痫妇女中测定了一种新的抗高血压药物拉贝洛尔对子宫胎盘血流的影响。注射0.5 mCi的113 mIn后，通过与计算机连接的伽马照相机记录胎盘中的放射性，并根据同位素蓄积曲线的最大放射性与曲线上升时间之间的比值计算胎盘血流指数。静脉给予拉贝洛尔（一种α和β肾上腺素受体拮抗剂），30分钟后计算第二次子宫胎盘血流指数。平均血压从147/98 mmHg显著降低至128/83 mmHg，但子宫胎盘血流指数无变化，因此子宫胎盘血管阻力趋于降低。
The effect of a new antihypertensive drug, labetalol, on uteroplacental blood flow was determined in eight pre‐eclamptic women. After injection of 0.5 mCi of113mIn the radioactivity in the placenta was recorded by a gamma camera linked to a computer and the placental blood‐flow index was calculated from the ratio between the maximum radioactivity of the isotope‐accumulation curve and the rise time of the curve. Labetalol, a combined α‐ and β‐adrenoceptor antagonist was given intravenously and after 30 min a second uteroplacental blood‐flow index was calculated. There was a significant mean decrease of blood pressure from 147/98 to 128/83 mmHg, but no change in uteroplacental blood‐flow index, so that uteroplacental vascular resistance tended to decrease.