Detection of lipid in atherosclerotic vessels using ultrasound-guided spectroscopic intravascular photoacoustic imaging.
Detection of lipid in atherosclerotic vessels using ultrasound-guided spectroscopic intravascular photoacoustic imaging.
复制标题
DOI：
10.1364/oe.18.004889
复制
发表时间：
2010-03-01
期刊：
影响因子：
3.8
通讯作者：
Emelianov S
中科院分区：
文献类型：
--
作者：
Wang B;Su JL;Amirian J;Litovsky SH;Smalling R;Emelianov S
脂质是动脉粥样硬化斑块的常见成分。脂质区的位置和面积与疾病的进展密切相关。血管内光声成像（IVPA）是一种微创成像方式，可以在空间上分辨动脉组织的光吸收特性。基于脂肪在近红外波长范围内的独特光学吸收光谱，光谱IVPA成像可以将脂质与动脉粥样硬化动脉中的其他水基组织类型区分开。在这项研究中，一个台式光谱IVPA成像系统被用来离体图像动脉粥样硬化和正常兔动脉粥样硬化。通过将光谱IVPA图像与血管内超声（IVUS）图像相结合，识别主动脉中的脂质区域。结果表明，IVUS引导的光谱IVPA成像是一个有前途的工具，以区分脂质动脉粥样硬化。
Lipid is a common constituent in atherosclerotic plaques. The location and area of the lipid region is closely related to the progression of the disease. Intravascular photoacoustic (IVPA) imaging, a minimally invasive imaging modality, can spatially resolve the optical absorption property of arterial tissue. Based on the distinct optical absorption spectrum of fat in the near infrared wavelength range, spectroscopic IVPA imaging may distinguish lipid from other water-based tissue types in the atherosclerotic artery. In this study, a bench-top spectroscopic IVPA imaging system was used to ex-vivo image both atherosclerotic and normal rabbit aortas. By combing the spectroscopic IVPA image with the intravascular ultrasound (IVUS) image, lipid regions in the aorta were identified. The results demonstrated that IVUS-guided spectroscopic IVPA imaging is a promising tool to differentiate lipid in atherosclerosis.