A clinical laboratory model for evaluating the acute effects of electronic "cigarettes": nicotine delivery profile and cardiovascular and subjective effects.
A clinical laboratory model for evaluating the acute effects of electronic "cigarettes": nicotine delivery profile and cardiovascular and subjective effects.
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用于评估电子“香烟”急性影响的临床实验室模型：尼古丁输送曲线以及心血管和主观影响。
DOI：
10.1158/1055-9965.epi-10-0288
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发表时间：
2010-08
影响因子：
3.8
通讯作者：
Eissenberg, Thomas E.
中科院分区：
文献类型：
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作者：
Vansickel, Andrea R.;Cobb, Caroline O.;Weaver, Michael F.;Eissenberg, Thomas E.
电子“香烟”（ECs）作为潜在减少暴露产品（PREPs）销售给烟草使用者，尽管关于电子香烟使用者的毒物暴露和影响的信息很少。这一信息可通过调整用于评估吸烟者其他预防措施的临床实验室方法获得。32名吸烟者参加了四个独立的拉丁方框条件，不同的产品：自有品牌香烟，“NPRO”EC（18毫克弹），“Hydro”EC（16毫克弹）或sham（未点燃的香烟）。在每次实验中，参与者在两个不同的时间抽了10次。评估血浆尼古丁和一氧化碳（CO）浓度、心率和主观影响。在给药的前五分钟内，自有品牌显著增加血浆尼古丁和CO浓度和心率，而“NPRO”EC、“Hydro”EC和假吸烟则没有。自有品牌，“NPRO”EC和“Hydro”EC（但不是假的）显著降低了烟草戒断症状评级和提高了产品可接受度评级。自主品牌患者的症状抑制程度和可接受度高于“NPRO”和“Hydro”。在这些急性测试条件下，两种ec都没有将使用者暴露于可测量水平的尼古丁或一氧化碳中，尽管两者都抑制了尼古丁/烟草戒断症状评分。这项研究说明了如何使用临床实验室方法来了解这些和其他prep对烟草使用者的急性影响。这里报告的结果和方法可能与ECs和类似产品的评估和基于经验的监管相关。
Electronic “cigarettes” (ECs) are marketed to tobacco users as potential reduced exposure products (PREPs), albeit with little information regarding EC user toxicant exposure and effects. This information may be obtained by adapting clinical laboratory methods used to evaluate other PREPs for smokers. Thirty-two smokers participated in four independent Latin-square ordered conditions that differed by product: own brand cigarette, “NPRO” EC (18 mg cartridge), “Hydro” EC (16 mg cartridge) or sham (unlit cigarette). Participants took 10 puffs at two separate times during each session. Plasma nicotine and carbon monoxide (CO) concentration, heart rate, and subjective effects were assessed. Own brand significantly increased plasma nicotine and CO concentration and heart rate within the first five minutes of administration while “NPRO” EC, “Hydro” EC, and sham smoking did not. Own brand, “NPRO” EC, and “Hydro” EC (but not sham) significantly decreased tobacco abstinence symptom ratings and increased product acceptability ratings. The magnitude of symptom suppression and increased acceptability was greater for own brand than for “NPRO” EC and “Hydro” EC. Under these acute testing conditions, neither of the ECs exposed users to measurable levels of nicotine or CO, though both suppressed nicotine/tobacco abstinence symptom ratings. This study illustrates how clinical laboratory methods can be used to understand the acute effects of these and other PREPs for tobacco users. The results and methods reported here will likely be relevant to the evaluation and empirically-based regulation of ECs and similar products.