Reduced gray matter volume in normal adults with a maternal family history of Alzheimer disease
Reduced gray matter volume in normal adults with a maternal family history of Alzheimer disease
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DOI：
10.1212/wnl.0b013e3181c918cb
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发表时间：
2010-01-12
期刊：
影响因子：
9.9
通讯作者：
Burns, J. M.
中科院分区：
文献类型：
--
作者：
Honea, R. A.;Swerdlow, R. H.;Burns, J. M.
目的：阿尔茨海默病（AD）的一个一致确定的危险因素是痴呆症的家族史，母亲传播比父亲传播更频繁。在认知健康的受试者中，母体AD病史可能与AD样葡萄糖消耗有关。在这项横断面研究中，我们测试了有AD家族史的认知健康人群的灰质体积（GMV）（迟发性AD的一种内表型）是否比无家族史的个体更少，以及GMV的减少是否与有母系家族史的受试者不同。方法：作为堪萨斯大学脑老化项目的一部分，67名有晚发性AD母亲病史的认知完整个体在3 T下扫描年龄、性别、教育程度和简易精神状态检查评分相似的父亲有AD病史（FHm，n = 16）、父亲有AD病史（FHp，n = 8）或父母无AD病史（FH-，n = 43）的患者。我们使用基于体素的形态测量法来检查组间GMV的差异，控制年龄、性别和apoE 4。结果：与FH-个体相比，具有迟发性AD家族史的认知健康个体在楔前叶、额中、额下和额上级脑回的GMV显著降低。FHm科目有显着较小的额下，额中，楔前叶，舌回相比FH和FHp subjects.Conclusions：总体而言，母亲的阿尔茨海默病（AD）家族史在认知正常的个人与较低的灰质体积在AD脆弱的大脑区域。这些数据补充和扩展了有母系家族史受试者脑代谢差异的报道。神经病学（R）2010;74：113-120
Objective: A consistently identified risk factor for Alzheimer disease (AD) is family history of dementia, with maternal transmission significantly more frequent than paternal transmission. A history of maternal AD may be related to AD-like glucose consumption in cognitively healthy subjects. In this cross-sectional study, we tested whether cognitively healthy people with a family history of AD have less gray matter volume (GMV), an endophenotype for late-onset AD, than individuals with no family history, and whether decreases in GMV are different in subjects with a maternal family history.Methods: As part of the Kansas University Brain Aging Project, 67 cognitively intact individuals with a maternal history of late-onset AD (FHm, n = 16), a paternal history of AD (FHp, n = 8), or no parental history of AD (FH-, n = 43), similar in age, gender, education, and Mini-Mental State Examination score, were scanned at 3 T. We used voxel-based morphometry to examine GMV differences between groups, controlling for age, gender, and apoE4.Results: Cognitively healthy individuals with a family history of late-onset AD had significantly decreased GMV in the precuneus, middle frontal, inferior frontal, and superior frontal gyri compared with FH- individuals. FHm subjects had significantly smaller inferior frontal, middle frontal, precuneus, and lingual gyri compared with FH- and FHp subjects.Conclusions: Overall, maternal family history of Alzheimer disease (AD) in cognitively normal individuals is associated with lower gray matter volume in AD-vulnerable brain regions. These data complement and extend reports of cerebral metabolic differences in subjects with a maternal family history. Neurology (R) 2010;74:113-120