High-field MRI reveals an acute impact on brain function in survivors of the magnitude 8.0 earthquake in China
High-field MRI reveals an acute impact on brain function in survivors of the magnitude 8.0 earthquake in China
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DOI：
10.1073/pnas.0812751106
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发表时间：
2009-09-08
影响因子：
11.1
通讯作者：
Gong, Qiyong
中科院分区：
文献类型：
--
作者：
Lui, Su;Huang, Xiaoqi;Gong, Qiyong
除了巨大的医疗和经济后果外，国家灾害，如汶川8.0级地震，也对幸存者的心理健康构成威胁。在这种情况下，需要更好地了解功能性大脑系统如何适应严重的情绪压力。先前的动物研究已经证明了边缘系统、边缘系统、纹状体和前额叶结构在压力和恐惧反应中的重要性。人类研究主要集中在临床确诊的创伤后应激障碍患者身上，报告了类似的大脑结构异常。目前，对创伤事件发生后不久创伤幸存者脑功能的潜在改变知之甚少。在这里，我们通过最近发现的一种称为“静息态”功能性MRI的方法，显示了汶川地震后25天内一组健康幸存者脑功能的变化。目前的调查表明，在额边缘和纹状体区域的区域活动显着增加，边缘和纹状体网络之间的连接减弱，在我们的参与者谁最近经历了严重的情感创伤。创伤受害者在休息状态脑功能的“默认模式”内的时间同步性也降低了，这在人类和其他物种中已经得到了表征。总之，我们的研究结果提供了证据表明，脑功能的显着变化，在许多方面与创伤后应激障碍中观察到的相似，可以在重大创伤经历后不久看到，强调需要对创伤幸存者进行早期评估和干预。
Besides the enormous medical and economic consequences, national disasters, such as the Wenchuan 8.0 earthquake, also pose a risk to the mental health of survivors. In this context, a better understanding is needed of how functional brain systems adapt to severe emotional stress. Previous animal studies have demonstrated the importance of limbic, paralimbic, striatal, and prefrontal structures in stress and fear responses. Human studies, which have focused primarily on patients with clinically established posttraumatic stress disorders, have reported abnormalities in similar brain structures. At present, little is known about potential alterations of brain function in trauma survivors shortly after traumatic events. Here, we show alteration of brain function in a cohort of healthy survivors within 25 days after the Wenchuan earthquake by a recently discovered method known as "resting-state'' functional MRI. The current investigation demonstrates that regional activity in frontolimbic and striatal areas increased significantly and connectivity among limbic and striatal networks was attenuated in our participants who had recently experienced severe emotional trauma. Trauma victims also had a reduced temporal synchronization within the "default mode'' of resting-state brain function, which has been characterized in humans and other species. Taken together, our findings provide evidence that significant alterations in brain function, similar in many ways to those observed in posttraumatic stress disorders, can be seen shortly after major traumatic experiences, highlighting the need for early evaluation and intervention for trauma survivors.