Repetitive transcranial magnetic stimulator with controllable pulse parameters.
Repetitive transcranial magnetic stimulator with controllable pulse parameters.
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DOI：
10.1088/1741-2560/8/3/036016
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发表时间：
2011-06
影响因子：
4
通讯作者：
Lisanby SH
中科院分区：
文献类型：
--
作者：
Peterchev AV;Murphy DL;Lisanby SH
经颅磁刺激脉冲的特性影响着经颅磁刺激的生理效应。然而，现有的TMS设备允许非常有限的脉冲参数调整。我们描述了一种新型TMS器件，该器件使用包含两个储能电容器和两个绝缘栅双极晶体管（IGBT）模块的电路拓扑来产生具有可调脉冲相位数量、极性、持续时间和幅度的近矩形电场脉冲。该可控脉冲参数TMS （cTMS）器件可产生相位宽度为10 ~ 310 μs、正负相位幅值比为1 ~ 56的电场脉冲。与传统的单相和双相TMS相比，cTMS减少了82%和57%的能量消耗，减少了33%和41%的线圈加热。我们展示了频率高达50 Hz的3000个脉冲的重复TMS序列，电场脉冲幅度和宽度的变化分别小于测量分辨率（1.7%和1%）。cTMS提供灵活的脉冲参数调节，降低功耗和线圈加热，增强了现有的TMS模式，实现了新的研究应用，并可能导致潜在的增强效力的临床应用。
The characteristics of transcranial magnetic stimulation (TMS) pulses influence the physiological effect of TMS. However, available TMS devices allow very limited adjustment of the pulse parameters. We describe a novel TMS device that uses a circuit topology incorporating two energy storage capacitors and two insulated-gate bipolar transistor (IGBT) modules to generate near-rectangular electric field pulses with adjustable number, polarity, duration, and amplitude of the pulse phases. This controllable pulse parameter TMS (cTMS) device can induce electric field pulses with phase widths of 10–310 μs and positive/negative phase amplitude ratio of 1–56. Compared to conventional monophasic and biphasic TMS, cTMS reduces energy dissipation by up to 82% and 57%, and decreases coil heating by up to 33% and 41%, respectively. We demonstrate repetitive TMS trains of 3,000 pulses at frequencies up to 50 Hz with electric field pulse amplitude and width variability less than the measurement resolution (1.7% and 1%, respectively). Offering flexible pulse parameter adjustment and reduced power consumption and coil heating, cTMS enhances existing TMS paradigms, enables novel research applications, and could lead to clinical applications with potentially enhanced potency.
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DOI：
10.1016/j.clinph.2009.08.016
发表时间：
2009-12
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Rossi S;Hallett M;Rossini PM;Pascual-Leone A;Safety of TMS Consensus Group
通讯作者：
Safety of TMS Consensus Group
影响因子：
10.6
作者：
O'Reardon, John P.;Solvason, H. Brent;Sackeim, Harold A.
通讯作者：
Sackeim, Harold A.
影响因子：
7.6
作者：
Lisanby, SH;Luber, B;Sackeim, HA
通讯作者：
Sackeim, HA
影响因子：
5.5
作者：
Pitcher, JB;Ogston, KM;Miles, TS
通讯作者：
Miles, TS
影响因子：
4.7
作者：
Arai, N;Okabe, S;Ugawa, Y
通讯作者：
Ugawa, Y