The Regulatory Role of Long Noncoding RNAs in Cancer Drug Resistance
The Regulatory Role of Long Noncoding RNAs in Cancer Drug Resistance
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DOI：
10.1007/978-1-4939-3347-1_12
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发表时间：
2016-01-01
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影响因子：
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通讯作者：
Baguley, Bruce C.
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文献类型：
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作者：
Askarian-Amiri, Marjan E.;Leung, Euphemia;Baguley, Bruce C.
最近的基因组和转录组分析表明，人类基因组的大部分转录为非蛋白质编码的RNA。这些转录本被称为长非编码RNA，具有与mRNA相似的结构。这些转录本中的许多现在被认为在不同的生物途径中具有调节作用，这些途径为细胞在基因表达和蛋白质组功能对刺激的反应中提供了额外的一层调节复杂性。因此，各种各样的细胞功能可能依赖于细胞信号网络中非编码RNA和其他关键分子之间相互作用的微调。许多非编码RNA的去调控被认为发生在各种人类疾病中，包括肿瘤和癌症耐药。在这里，我们讨论了最近发现的分子功能的长非编码RNA在细胞通路中，介导抗癌药物的耐药性。
Recent genomic and transcriptomic analysis has revealed that the majority of the human genome is transcribed as nonprotein-coding RNA. These transcripts, known as long noncoding RNA, have structures similar to those of mRNA. Many of these transcripts are now thought to have regulatory roles in different biological pathways which provide cells with an additional layer of regulatory complexity in gene expression and proteome function in response to stimuli. A wide variety of cellular functions may thus depend on the fine-tuning of interactions between noncoding RNAs and other key molecules in cell signaling networks. Deregulation of many noncoding RNAs is thought to occur in a variety of human diseases, including neoplasia and cancer drug resistance. Here we discuss recent findings on the molecular functions of long noncoding RNAs in cellular pathways mediating resistance to anticancer drugs.