A targeted door-to-door strategy for sleeping sickness detection in low-prevalence settings in Cote d'Ivoire
A targeted door-to-door strategy for sleeping sickness detection in low-prevalence settings in Cote d'Ivoire
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DOI：
10.1051/parasite/2016059
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发表时间：
2016-11-16
期刊：
影响因子：
2.9
通讯作者：
Jamonneau, Vincent
中科院分区：
文献类型：
--
作者：
Koffi, Mathurin;N'Djetchi, Martial;Jamonneau, Vincent
过去三十年来，科特迪瓦为控制人类非洲锥虫病 (HAT) 所做的重大努力已导致疾病患病率大幅下降。在这种背景下，昂贵且劳动密集型的主动大规模筛查策略不再有效。除了在这种低流行情况下实施更具成本效益的被动监测系统外，我们的目标是开发一种替代的有针对性的主动筛查策略。 2012 年，我们开展了一项有针对性的挨家挨户 (TDD) 调查，重点关注在博农 (Bonon) HAT 焦点发现的前 HAT 患者的邻近地区，并将结果与 2000 年至 2012 年在同一地区进行的经典主动大规模筛查 (AMS) 调查期间获得的结果进行比较。 TDD 提供了一个更友好的环境，邀请居民参与并提高对该疾病的认识，发现的 HAT 病例明显多于 AMS。这些结果表明，在低流行率环境中，TDD 是一种有效且有用的策略，在这些环境中，非常局部的传播周期可能持续存在，并且与被动监测相结合，可以帮助消除 HAT。
Significant efforts to control human African trypanosomiasis (HAT) over the three past decades have resulted in drastic reductions of disease prevalence in Cote d'Ivoire. In this context, the costly and labor-intensive active mass screening strategy is no longer efficient. In addition to a more cost-effective passive surveillance system being implemented in this low-prevalence context, our aim was to develop an alternative targeted active screening strategy. In 2012, we carried out a targeted door-to-door (TDD) survey focused on the immediate vicinities of former HAT patients detected in the HAT focus of Bonon and compared the results to those obtained during classical active mass screening (AMS) surveys conducted from 2000 to 2012 in the same area. The TDD that provides a friendlier environment, inviting inhabitants to participate and gain awareness of the disease, detected significantly more HAT cases than the AMS. These results suggest that the TDD is an efficient and useful strategy in low-prevalence settings where very localized transmission cycles may persist and, in combination with passive surveillance, could help in eliminating HAT.