Enhanced hippocampal acetylcholine release in nociceptin-receptor knockout mice
Enhanced hippocampal acetylcholine release in nociceptin-receptor knockout mice
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DOI：
10.1016/j.brainres.2005.05.044
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发表时间：
2005-07
期刊：
影响因子：
2.9
通讯作者：
K. Uezu;A. Sano;H. Sei;K. Toida;T. Houtani;T. Sugimoto;Toshiko Suzuki-Yamamoto;H. Takeshima;K. Ishimura;Y. Morita
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文献类型：
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作者：
K. Uezu;A. Sano;H. Sei;K. Toida;T. Houtani;T. Sugimoto;Toshiko Suzuki-Yamamoto;H. Takeshima;K. Ishimura;Y. Morita
伤害感受肽 (NOC) 是阿片受体样 1 受体的内源性配体，被认为参与学习和记忆过程。由于乙酰胆碱（ACh）参与海马功能，而海马对学习和记忆功能起着至关重要的作用，因此采用体内微透析方法检测NOC受体敲除小鼠海马ACh的释放。基因敲除小鼠海马乙酰胆碱的释放大大增加。此外，在基因敲除小鼠中，还观察到海马θ节律增强，已知这与海马记忆功能有关。免疫组织化学证实，在隔膜中，NOC 受体与胆碱能神经元共存，但不与 GABA 能神经元共存。研究结果表明，NOC 受体参与海马胆碱能功能。
Nociceptin (NOC), an endogenous ligand of the opioid receptor-like 1 receptor, is thought to be involved in learning and memory processes. Since acetylcholine (ACh) is involved in hippocampal function, and the hippocampus plays a critical role on the learning and memory function, hippocampal ACh release in NOC-receptor knockout mice was examined using an in vivo microdialysis method. The release of hippocampal ACh was largely increased in the knockout mice. Furthermore, in the knockout mice, an enhanced hippocampal theta rhythm, which is known to be linked to hippocampal memory function, was also observed. Immunohistochemically, in septum, co-existence of NOC receptor with cholinergic, but not with GABAergic neurons, was verified. The findings demonstrate that the NOC receptor is involved in hippocampal cholinergic function.