Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis
Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis
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DOI：
10.1192/bjp.bp.107.046649
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发表时间：
2008-04-01
影响因子：
10.5
通讯作者：
Curran, H. Valerie
中科院分区：
文献类型：
--
作者：
Morgan, Celia J. A.;Curran, H. Valerie
大麻含有多种大麻素，其中两种具有几乎相反的作用：Delta 9-四氢大麻酚(Delta 9-THC)具有拟精神分裂症作用，而大麻二醇(CBD)具有抗精神病作用。对140名个体的头发样本进行了分析，以检测Delta 9-THC和CBD的水平。出现了三个明显的组：只有THC，THC+CBD，以及头发中没有大麻素的人。与没有大麻素组和THC+CBD组相比，仅THC组显示出更高水平的阳性精神分裂症样症状，与没有大麻素组相比，更高水平的妄想。这为大麻类物质的不同性质提供了证据，并对研究大麻使用和精神疾病之间的联系具有重要意义。
Cannabis contains various cannabinoids, two of which have almost opposing actions: Delta 9-tetrahydrocannabinol (Delta 9-THC) is psychotomimetic, whereas cannabidiol (CBD) has antipsychotic effects. Hair samples were analysed to examine levels of Delta 9-THC and CBD in 140 individuals. Three clear groups emerged: 'THC only', 'THC+CBD' and those with no cannabinoid in hair. The THC only group showed higher levels of positive schizophrenia-like symptoms compared with the no cannabinoid and THC+CBD groups, and higher levels of delusions compared with the no cannabinoid group. This provides evidence of the divergent properties of cannabinoids and has important implications for research into the link between cannabis use and psychosis.Declaration of interestNone.