I-FABP Is Higher in People With Chronic HIV Than Elite Controllers, Related to Sugar and Fatty Acid Intake and Inversely Related to Body Fat in People With HIV
I-FABP Is Higher in People With Chronic HIV Than Elite Controllers, Related to Sugar and Fatty Acid Intake and Inversely Related to Body Fat in People With HIV
复制标题
DOI：
10.1093/ofid/ofy288
复制
发表时间：
2018-11-01
影响因子：
4.2
通讯作者：
Lo, Janet
中科院分区：
文献类型：
--
作者：
Cheru, Lediya T.;Park, Elli A.;Lo, Janet
背景肠道脂肪酸结合蛋白（I-FABP）已被证明是艾滋病毒感染者肠道损伤的标志物。我们假设I-FABP在慢性HIV感染者中比在精英控制者中增加更多，并且与特定的营养摄入和身体成分有关。在一项观察性研究中，采用酶联免疫吸附试验测定血清I-FABP。获得人体测量、双能X线吸收测量和单层腹部计算机断层扫描以评估身体组成以及内脏和皮下脂肪组织面积（VAT和SAT）。膳食摄入量采用4天的食物记录进行评估。149名慢性HIV感染者（65%男性，47 +/- 7岁，54.7%白色，14 +/- 6岁已知艾滋病毒），10名精英控制者（60%男性，53 +/- 8岁，60%白色，20 +/- 7岁已知HIV）和69例HIV阴性对照（59.4%男性，46 +/- 7岁，52.2%白色）纳入分析。I-FABP在HIV进展者中显著高于HIV阴性对照和精英控制者。在慢性HIV组中，I-FABP与饮食中添加糖和饱和脂肪酸的摄入呈正相关。I-FABP与体重指数、VAT和SAT呈负相关。在所有参与者中，I-FABP还与MCP-1、CXCL 10、sCD 163和脂多糖（LPS）相关。I-FABP在慢性HIV感染者中的增加程度高于精英控制者，并且与HIV进展者的营养摄入和身体成分有关。需要进一步研究肠道损伤对营养吸收的作用，以阐明这些关系的机制。
Background. Intestinal fatty acid binding protein (I-FABP) has been shown to be a marker of intestinal damage among people living with HIV. We hypothesized that I-FABP would be increased in chronically HIV-infected patents more than elite controllers and would relate to specific nutrient intake and body composition.Methods. In an observational study, serum I-FABP was measured by enzyme-linked immunosorbent assay. Anthropometric measurements, dual-energy x-ray absorptiometry, and single-slice abdominal computed tomography were obtained to assess body composition, as well as visceral and subcutaneous adipose tissue areas (VAT and SAT). Dietary intake was assessed using 4-day food records.Results. One hundred forty-nine people with chronic HIV (65% male, 47 +/- 7 years of age, 54.7% white, and 14 +/- 6 years of known HIV), 10 elite controllers (60% male, 53 +/- 8 years, 60% white, and 20 +/- 7 years of known HIV), and 69 HIV-negative controls (59.4% male, 46 +/- 7 years, and 52.2% white) were included in the analysis. I-FABP was significantly higher in HIV progressors relative to HIV-negative controls and elite controllers. In the chronic HIV group, I-FABP was positively associated with dietary intake of added sugar and with saturated fatty acids. I-FABP was inversely associated with body mass index, VAT, and SAT. I-FABP also correlated with MCP-1, CXCL10, sCD163, and lipopolysaccharide (LPS) among all participants.Conclusions. I-FABP was increased among chronically HIV-infected patients to a greater degree than in elite controllers and was related to nutrient intake and body composition in HIV progressors. Future studies to investigate the role of intestinal damage on nutrient absorption are needed to elucidate the mechanisms of these relationships.