Nestin expression in vascular malformations: a novel marker for proliferative endothelium.
Nestin expression in vascular malformations: a novel marker for proliferative endothelium.
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DOI：
10.2176/nmc.46.111
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发表时间：
2006-03
影响因子：
1.9
通讯作者：
Tatsuya Shimizu;Ken-ichi Sugawara;M. Tosaka;Hideaki Imai;K. Hoya;T. Takeuchi;Tomio Sasaki;N. Saito
中科院分区：
文献类型：
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作者：
Tatsuya Shimizu;Ken-ichi Sugawara;M. Tosaka;Hideaki Imai;K. Hoya;T. Takeuchi;Tomio Sasaki;N. Saito
海绵状血管瘤（CAs）和动静脉畸形（AVMs）有时表现为生长或新生。内皮细胞的增殖能力在这种畸形中是明显的。中间丝巢蛋白是一种新发现的增殖内皮标志物，最初在胚胎中枢神经系统的神经上皮干细胞中检测到。通过与增殖细胞核抗原（PCNA）比较，免疫组化分析评价巢蛋白作为内皮细胞增殖能力的标志物。27例ca中有16例，20例avm中有13例nestin阳性。同样，27例ca中有12例，20例avm中有10例PCNA阳性。内皮细胞和间质细胞的Nestin染色在典型的ca畸形血管中强于在AVMs中。新形成的内皮细胞在反应性组织中表达巢蛋白，包括组织血肿或包被血肿。这些结果表明，新生血管发生在血肿反复出血和重塑的过程中。
Cavernous angiomas (CAs) and arteriovenous malformations (AVMs) sometimes show growth or de novo appearance. Proliferative capacity of the endothelium is evident in such malformations. Intermediate filament nestin is a newly identified marker for proliferative endothelium, which was originally detected in the neuroepithelial stem cells of the embryonal central nervous system. Immunohistochemical analysis of nestin was evaluated as a marker for proliferative capacity of endothelial cells by comparison with proliferating cell nuclear antigen (PCNA). Sixteen of 27 CAs and 13 of 20 AVMs were positive for nestin. Likewise, 12 of 27 CAs and 10 of 20 AVMs were positive for PCNA. Nestin staining was stronger in the typical malformative vessels of CAs than in AVMs, in both the endothelial cells and the interstitial cells. Newly formed endothelial cells expressed nestin strongly in the reactive tissues including organizing or encapsulated hematomas. These results suggest that neovascularization occurs in the process of repeated bleeding and remodeling of hematomas.