Cattle Ly49 is polymorphic
Cattle Ly49 is polymorphic
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DOI：
10.1007/s00251-009-0406-7
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发表时间：
2009-12-01
期刊：
影响因子：
3.2
通讯作者：
Ellis, Shirley A.
中科院分区：
文献类型：
--
作者：
Dobromylskyj, Melanie J.;Connelley, Timothy;Ellis, Shirley A.
牛是唯一一种具有扩展的KIR基因家族的非灵长类物种。此外，它们还有一个Ly49基因，被认为是单态的。我们已经确定了两个额外的Ly49 cDNA序列在牛的编码分子预测不同的14和16个氨基酸的原始序列。所有可用的数据表明，只有一个Ly49基因在牛的存在下，因此，不同的序列报告这里可能代表古老的等位基因谱系，在祖先基因或以前扩大，随后收缩Ly49基因家族的多态性的高水平。牛是唯一已知具有扩展的多态性KIR基因家族和多态性Ly49基因的物种。
Cattle are the only non-primate species to have an expanded KIR gene family. In addition they have a single Ly49 gene, thought to be monomorphic. We have identified two additional Ly49 cDNA sequences in cattle that encode molecules predicted to differ by 14 and 16 amino acids from the original sequence. All available data indicate the presence of only one Ly49 gene in cattle, thus the divergent sequences reported here may represent ancient allelic lineages, a high level of polymorphism in an ancestral gene or a previously expanded and subsequently contracted Ly49 gene family. Cattle are the only species known to have an expanded polymorphic KIR gene family and a polymorphic Ly49 gene.